XTP3-transactivated gene A protein

dCTP pyrophosphatase 1 is an enzyme that in humans is encoded by the DCTPP1 gene.[5][6]

DCTPP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2A3Q, 2OIE, 2OIG, 2Q4P
Identifiers
Aliases	DCTPP1, RS21C6, XTP3TPA, CDA03, XTP3-transactivated gene A protein, dCTP pyrophosphatase 1
External IDs	OMIM: 615840 MGI: 1913672 HomoloGene: 11329 GeneCards: DCTPP1
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p11.2 Start 30,423,615 bp[1] End 30,430,030 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F3 Start 127,256,959 bp[2] End 127,260,709 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleotide binding • pyrophosphatase activity • GO:0001948 protein binding • hydrolase activity • magnesium ion binding • metal ion binding • identical protein binding • pyrimidine deoxyribonucleotide binding • dCTP diphosphatase activity • nucleoside-triphosphate diphosphatase activity Cellular component • cytoplasm • cytosol • cell nucleus • mitochondrion Biological process • protein homotetramerization • dCTP catabolic process • nucleoside triphosphate catabolic process • DNA protection • dTTP catabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	79077	66422
Ensembl	ENSG00000179958	ENSMUSG00000042462
UniProt	Q9H773	Q9QY93
RefSeq (mRNA)	NM_024096	NM_023203
RefSeq (protein)	NP_077001	NP_075692
Location (UCSC)	Chr 16: 30.42 – 30.43 Mb	Chr 7: 127.26 – 127.26 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Deoxycytidine triphosphate (dCTP)
• Transactivation

References

1. GRCh38: Ensembl release 89: ENSG00000179958 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000042462 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Moroz OV, Murzin AG, Makarova KS, Koonin EV, Wilson KS, Galperin MY (Mar 2005). "Dimeric dUTPases, HisE, and MazG belong to a new superfamily of all-alpha NTP pyrophosphohydrolases with potential "house-cleaning" functions". J Mol Biol. 347 (2): 243–55. doi:10.1016/j.jmb.2005.01.030. PMID 15740738.
6. "Entrez Gene: XTP3TPA XTP3-transactivated protein A".

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.