XIRP2

Xin actin-binding repeat-containing protein 2 is a protein that in humans is encoded by the XIRP2 gene.[5][6][7][8]

XIRP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4F14
Identifiers
Aliases	XIRP2, CMYA3, xin actin binding repeat containing 2
External IDs	OMIM: 609778 MGI: 2685198 HomoloGene: 19388 GeneCards: XIRP2
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q24.3 Start 166,888,487 bp[1] End 167,259,753 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 C1.3 Start 67,173,834 bp[2] End 67,526,615 bp[2]
Gene ontology Molecular function • alpha-actinin binding • actin binding • actin filament binding Cellular component • cell junction • Z disc • stress fiber • focal adhesion • filamentous actin Biological process • heart development • cell-cell junction organization • cardiac muscle tissue morphogenesis • ventricular septum development • actin cytoskeleton organization • biological process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	129446	241431
Ensembl	ENSG00000163092	ENSMUSG00000027022
UniProt	A4UGR9	Q4U4S6
RefSeq (mRNA)	NM_152381 NM_001079810 NM_001199143 NM_001199144 NM_001199145	NM_001024618 NM_001083919
RefSeq (protein)	NP_001073278 NP_001186072 NP_001186073 NP_001186074 NP_689594	NP_001019789 NP_001077388
Location (UCSC)	Chr 2: 166.89 – 167.26 Mb	Chr 2: 67.17 – 67.53 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000163092 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027022 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Huang HT, Brand OM, Mathew M, Ignatiou C, Ewen EP, McCalmon SA, Naya FJ (Dec 2006). "Myomaxin is a novel transcriptional target of MEF2A that encodes a Xin-related alpha-actinin-interacting protein". J Biol Chem. 281 (51): 39370–9. doi:10.1074/jbc.M603244200. PMID 17046827.
6. Sinn HW, Balsamo J, Lilien J, Lin JJ (Aug 2002). "Localization of the novel Xin protein to the adherens junction complex in cardiac and skeletal muscle during development". Dev Dyn. 225 (1): 1–13. doi:10.1002/dvdy.10131. PMID 12203715.
7. Pacholsky D, Vakeel P, Himmel M, Lowe T, Stradal T, Rottner K, Furst DO, van der Ven PF (Oct 2004). "Xin repeats define a novel actin-binding motif". J Cell Sci. 117 (Pt 22): 5257–68. doi:10.1242/jcs.01406. PMID 15454575.
8. "Entrez Gene: CMYA3 cardiomyopathy associated 3".

Further reading

• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Blasi F, Bacchelli E, Carone S, et al. (2006). "SLC25A12 and CMYA3 gene variants are not associated with autism in the IMGSAC multiplex family sample". Eur. J. Hum. Genet. 14 (1): 123–6. doi:10.1038/sj.ejhg.5201444. PMID 16205742.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Pan PW, Li K, Tuggle CK, et al. (2004). "Sequencing, tissue distribution and physical mapping of the porcine homologue of cardiomyopathy associated 3 (CMYA3)". Anim. Genet. 34 (6): 473–4. doi:10.1046/j.0268-9146.2003.01059.x. PMID 14687087.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.