XAB2

Pre-mRNA-splicing factor SYF1 is a protein that in humans is encoded by the XAB2 gene.[5][6]

XAB2
Identifiers
Aliases	XAB2, HCNP, HCRN, NTC90, SYF1, XPA binding protein 2
External IDs	OMIM: 610850 MGI: 1914689 HomoloGene: 5738 GeneCards: XAB2
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.2 Start 7,619,525 bp[1] End 7,629,545 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 A1.1|8 1.92 cM Start 3,608,421 bp[2] End 3,621,316 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • catalytic step 2 spliceosome • membrane • nucleoplasm • spliceosomal complex • cell nucleus • Prp19 complex • prespliceosome • catalytic step 1 spliceosome • post-mRNA release spliceosomal complex • U2-type catalytic step 2 spliceosome Biological process • RNA processing • mRNA processing • transcription, DNA-templated • cellular response to DNA damage stimulus • RNA splicing • cerebral cortex development • transcription-coupled nucleotide-excision repair • blastocyst development • DNA repair • mRNA splicing, via spliceosome • generation of catalytic spliceosome for first transesterification step Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	56949	67439
Ensembl	ENSG00000076924	ENSMUSG00000019470
UniProt	Q9HCS7	Q9DCD2
RefSeq (mRNA)	NM_020196	NM_026156
RefSeq (protein)	NP_064581	NP_080432
Location (UCSC)	Chr 19: 7.62 – 7.63 Mb	Chr 8: 3.61 – 3.62 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

XAB2 has been shown to interact with ERCC8[5] and XPA.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000076924 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000019470 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nakatsu Y, Asahina H, Citterio E, Rademakers S, Vermeulen W, Kamiuchi S, Yeo JP, Khaw MC, Saijo M, Kodo N, Matsuda T, Hoeijmakers JH, Tanaka K (Nov 2000). "XAB2, a novel tetratricopeptide repeat protein involved in transcription-coupled DNA repair and transcription". J. Biol. Chem. 275 (45): 34931–7. doi:10.1074/jbc.M004936200. PMID 10944529.
6. "Entrez Gene: XAB2 XPA binding protein 2".

Further reading

• Hirosawa M, Nagase T, Ishikawa K, Kikuno R, Nomura N, Ohara O (1999). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res. 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID 10574461.
• Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, Zhou X, Li H, Qiu X, Zhong F, He L, Yu J, Yao G, Jiang H, Qian L, Yu Y, Shu H, Chen X, Xu H, Guo M, Pan Z, Chen Y, Ge C, Yang S, Gu J (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.