William Poole (disambiguation)
William Poole (1821–1855), also known as "Bill the Butcher", was an American gang member and leader of the Know Nothing political movement
William Poole may also refer to:
- William Frederick Poole (1821–1894), American bibliographer and librarian
- William Poole (Australian politician) (1828–1902), New South Wales politician
- William A. Poole (1831–1903), merchant and politician from Prince Edward Island, Canada
- William B. Poole (1833–1904), American sailor and Medal of Honor recipient
- William Wortham Poole (1842–1922), American bookkeeper
- William Henry Evered Poole (1902–1969), South African military commander and diplomat
- William Poole (economist) (born 1937), American economist, former president of the Federal Reserve Bank of St. Louis
- William H. Poole (1820–1896), Canadian minister and writer
- William H. Poole (politician), member of the California legislature
- William Henry Poole (1876–1921), college football player and minister
- William Mansfield Poole (1871–1946), educationalist and author
- William Leslie Poole (1866–1931), English immigrant to Uruguay important to the development of association football in Uruguay
- William T. Poole, 20th-century American research analyst for the US Congress
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