WIPF2

WAS/WASL-interacting protein family member 2 is a protein that in humans is encoded by the WIPF2 gene.[5][6][7]

WIPF2
Identifiers
Aliases	WIPF2, WICH, WIRE, WAS/WASL interacting protein family member 2
External IDs	OMIM: 609692 MGI: 1924462 HomoloGene: 15777 GeneCards: WIPF2
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.2 Start 40,219,304 bp[1] End 40,284,136 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 D Start 98,863,638 bp[2] End 98,905,040 bp[2]
Gene ontology Molecular function • actin binding • GO:0001948 protein binding • actin filament binding Cellular component • cytoplasm • cytosol • cytoskeleton • nucleoplasm • cell membrane • actin filament • actin cortical patch Biological process • Fc-gamma receptor signaling pathway involved in phagocytosis • actin cortical patch assembly • endocytosis • actin filament-based movement • positive regulation of actin nucleation • actin cortical patch localization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	147179	68524
Ensembl	ENSG00000171475	ENSMUSG00000038013
UniProt	Q8TF74	Q6PEV3
RefSeq (mRNA)	NM_133264	NM_197940
RefSeq (protein)	NP_573571	NP_922922
Location (UCSC)	Chr 17: 40.22 – 40.28 Mb	Chr 11: 98.86 – 98.91 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a WASP interacting protein (WIP)-related protein. It has been shown that this protein has a role in the WASP-mediated organization of the actin cytoskeleton and that this protein is a potential link between the activated platelet-derived growth factor receptor and the actin polymerization machinery.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000171475 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038013 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Aspenstrom P (Sep 2002). "The WASP-binding protein WIRE has a role in the regulation of the actin filament system downstream of the platelet-derived growth factor receptor". Exp Cell Res. 279 (1): 21–33. doi:10.1006/excr.2002.5576. PMID 12213210.
6. Kato M, Miki H, Kurita S, Endo T, Nakagawa H, Miyamoto S, Takenawa T (Feb 2002). "WICH, a novel verprolin homology domain-containing protein that functions cooperatively with N-WASP in actin-microspike formation". Biochem Biophys Res Commun. 291 (1): 41–7. doi:10.1006/bbrc.2002.6406. PMID 11829459.
7. "Entrez Gene: WIPF2 WAS/WASL interacting protein family, member 2".

Further reading

• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Salazar MA, Kwiatkowski AV, Pellegrini L, et al. (2004). "Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton". J. Biol. Chem. 278 (49): 49031–43. doi:10.1074/jbc.M308104200. PMID 14506234.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.