WFIKKN1

WAP, kazal, immunoglobulin, kunitz and NTR domain-containing protein 1 is a protein that is encoded by the WFIKKN1 gene.[5][6][7] when found in humans.

WFIKKN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DDI, 2DDJ
Identifiers
Aliases	WFIKKN1, C16orf12, RJD2, WFDC20A, WFIKKN, WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
External IDs	OMIM: 608021 MGI: 2670967 HomoloGene: 14244 GeneCards: WFIKKN1
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.3 Start 629,239 bp[1] End 634,117 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 A3.3 Start 25,877,628 bp[2] End 25,880,858 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • peptidase inhibitor activity • GO:0048551 enzyme inhibitor activity • GO:0001948 protein binding • metalloendopeptidase inhibitor activity • serine-type endopeptidase inhibitor activity • receptor antagonist activity • transforming growth factor beta binding Cellular component • extracellular region Biological process • skeletal system development • negative regulation of DNA binding • palate development • negative regulation of peptidase activity • muscle fiber development • negative regulation of protein binding • negative regulation of endopeptidase activity • negative regulation of transforming growth factor beta receptor signaling pathway • extracellular negative regulation of signal transduction • negative regulation of receptor activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	117166	215001
Ensembl	ENSG00000127578	ENSMUSG00000071192
UniProt	Q96NZ8	Q8R0S6
RefSeq (mRNA)	NM_053284	NM_001100454
RefSeq (protein)	NP_444514	NP_001093924
Location (UCSC)	Chr 16: 0.63 – 0.63 Mb	Chr 17: 25.88 – 25.88 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a secreted multidomain protein consisting of a signal peptide, a WAP domain, a follistatin domain, an immunoglobulin domain, two tandem Kunitz domains, and an NTR domain. These domains have been implicated frequently in inhibition of various types of proteases, suggesting that the encoded protein may be a multivalent protease inhibitor and may control the action of multiple types of serine proteases as well as metalloproteinases.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000127578 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000071192 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Trexler M, Banyai L, Patthy L (Mar 2001). "A human protein containing multiple types of protease-inhibitory modules". Proc Natl Acad Sci U S A. 98 (7): 3705–9. doi:10.1073/pnas.061028398. PMC 31116. PMID 11274388.
6. Trexler M, Banyai L, Patthy L (Apr 2002). "Distinct expression pattern of two related human proteins containing multiple types of protease-inhibitory modules". Biol Chem. 383 (1): 223–8. doi:10.1515/BC.2002.023. PMID 11928817.
7. "Entrez Gene: WFIKKN1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1".

Further reading

• Liepinsh E, Nagy A, Trexler M, et al. (2006). "Second Kunitz-type protease inhibitor domain of the human WFIKKN1 protein". J. Biomol. NMR. 35 (1): 73–8. doi:10.1007/s10858-006-9013-1. PMID 16791741.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
• Nagy A, Trexler M, Patthy L (2003). "Expression, purification and characterization of the second Kunitz-type protease inhibitor domain of the human WFIKKN protein". Eur. J. Biochem. 270 (9): 2101–7. doi:10.1046/j.1432-1033.2003.03593.x. PMID 12709070.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. doi:10.1093/hmg/10.4.339. PMID 11157797.