WD repeat domain 18

WD repeat domain 18 is a protein that in humans is encoded by the WDR18 gene. [4]

WDR18
Identifiers
Aliases	WDR18, Ipi3, R32184_1, WD repeat domain 18
External IDs	MGI: 2158400 HomoloGene: 32573 GeneCards: WDR18
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 984,271 bp[1] End 998,438 bp[1]
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • cell nucleus • cytoplasm • nucleoplasm • nucleolus • nuclear pre-replicative complex • Rix1 complex Biological process • multicellular organism development • rRNA processing • ribosomal large subunit assembly • pre-replicative complex assembly involved in nuclear cell cycle DNA replication • regulation of DNA-dependent DNA replication initiation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	57418	216156
Ensembl	ENSG00000065268	n/a
UniProt	Q9BV38	Q4VBE8
RefSeq (mRNA)	NM_024100 NM_001372085 NM_001372086	NM_175450
RefSeq (protein)	NP_077005 NP_001359014 NP_001359015	NP_780659
Location (UCSC)	Chr 19: 0.98 – 1 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation.

References

1. GRCh38: Ensembl release 89: ENSG00000065268 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Entrez Gene: WD repeat domain 18". Retrieved 2017-08-12.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.