W. P. Andrew Lee
Wei-Ping Andrew Lee (Chinese: 李為平; born c. 1957) is a Taiwanese-American hand surgeon and medical researcher. He is presently the dean of the University of Texas Southwestern Medical School and executive vice president for academic affairs and provost of UT Southwestern Medical Center.[1] Lee focuses on translational research on immune modulation for vascularized composite allotransplantation (VCA) and the implementation of protocols to minimize immunosuppression in hand transplant and other VCA programs.
Early life and education
Lee was born in the town of Gangshan in Kaohsiung, Taiwan, where his father Lee Hsueh-yan was serving in the Republic of China Air Force.[2][3] He immigrated to the United States at the age of 15 to join his siblings.[1][2][4] He followed his siblings to different towns due to their job re-location, and went to three high schools in three years while adapting to his new country and learning a new language.
Lee graduated with honors from Harvard College in 1979 with a bachelor's degree in physics. He received his medical degree from Johns Hopkins School of Medicine. He received plastic surgery training at the Massachusetts General Hospital and completed his orthopedic hand fellowship at the Indiana Hand to Shoulder Center. In 1991, he joined the academic faculty at Massachusetts General Hospital, Harvard Medical School[1], where he became the Director of Plastic Surgery Research Laboratory and Chief of Hand Service in Department of Surgery.
Career
In 2002, Lee was named the division chief of plastic surgery at the University of Pittsburgh School of Medicine and moved to Johns Hopkins Hospital in 2010 in the Department of Plastic and Reconstructive Surgery.[5] From 2010 to 2019, he was the Milton T. Edgerton, M.D., Professor and Chairman of the Department of Plastic and Reconstructive Surgery at Johns Hopkins.[6] He chaired the Associate Professor Promotion Committee of the Johns Hopkins School of Medicine from 2014 to 2017 and was Chair of the Medical Board from 2016 to 2018.
In 2019, Lee became the 16th dean of the University of Texas Southwestern Medical School and executive vice president for academic affairs and provost of UT Southwestern Medical Center where he is professor of plastic surgery and holds the Atticus James Gill, M.D. Chair in Medical Science.[1]
Research
He has led one of the largest hand and arm transplant programs in the field, and his group was especially focused on restoring functions to military servicemen with upper extremity amputations that resulted from combat injuries.[1][7][8][9]
In March 2018, Lee oversaw the team that performed the world’s first total penis and scrotum transplant. The operation included transplants of the penis, scrotum, and abdominal wall to a wounded serviceman and was the most complex surgery of its type.[2][4][10][11][12]
Lee has authored about 230 original peer-reviewed publications and 40 textbook chapters and co-edited the book Transplantation of Composite Tissue Allografts, (2008). He has served on the editorial boards of Transplantation, Journal of Surgical Research' and Hand. He co-founded Vascularized Composite Allo-transplantation in 2014 and serves as its co-Editor.
Publications
- Lee WPA, Yaremchuk MJ, Pan YC, Randolph MA, Tan CM, Weiland AJ. Relative Antigenicity of Components of a Vascularized Limb Allograft. Plastic Reconstructive Surg, 87:401, 1991.
- Lee WPA, Mathes D. Hand Transplantation: Pertinent Data/Future Outlook. J Hand Surg, 24A:906, 1999.
- Lee WPA, Rubin JP, Bourget JL, Cober SR, Randolph MA, Nielsen GP, Ierino FL, Sachs DH. Tolerance to Limb Tissue Allografts B/w Swine Matched for Major Histocompatibility Complex Antigens. Plastic Reconstr Surg, 107:1482, 2001.
- Mathes DW, Randolph MA, Solari MG, Nazzal JA, Nielson GP, Arn JS, Sachs DH, Lee WPA. Split Tolerance to a Composite Tissue Allograft in a Swine Model. Transplantation, 75:25-31, 2003.
- Hettiaratchy S, Melendy E, Randolph MA, Coburn RC, Neville DM, Sachs DH, Huang C, Lee WPA. Tolerance to Composite Tissue Allografts Across a Major Histocompatibility Barrier in Miniature Swine. Transplantation, 77:514, 2004.
- Solari MG, Washington KM, Sacks JM, Hautz T, Unadkat JV, Horibe E, Venkataramanan R, Larregina AT, Thomson AW, Lee WPA. Daily Topical Tacrolimus Therapy Prevents Skin Rejection in a Rodent Hind Limb Allograft Model. Plast Reconstr Surg, 123:17S-25S, 2009.
- Unadkat J, Schneeberger S, Horibe EH, Goldbach C, Solari MG, Washington KM, Gorantla VS, Cooper GM, Thomson AW, Lee WPA. Composite Tissue Vasculopathy and Degeneration Following Multiple Episodes of Acute Rejection in Reconstructive Transplantation. Am J Transplant, 10:251, 2010.
- Schneeberger S, Gorantla VS, Brandacher G, Zeevi A, Demetris AJ, Lunz JG, Metes DM, Donnenberg AD, Shores JT, Dimartini AF, Kiss JE, Imbriglia JE, Azari K, Goitz RJ, Manders EK, Nguyen VT, Cooney DS, Wachtman GS, Keith J, Fletcher D, Macedo C, Planinsic R, Losee J, Shapiro R, Starzl TE, Lee WPA. Upper Extremity Transplantation Using a Cell-Based Protocol to Minimize Immunosuppression. Ann Surg, 257:345-351, 2013.
- Shores JT, Brandacher G, Lee WPA. Hand and Upper Extremity Transplantation: An Update of Outcomes in the Worldwide Experience. Plast Reconstr Surg, 135(2):351e-360e, 2015
- Lee WPA. Hand Transplantation: Evolution of a Personal Outlook. J Hand Surg, 42(4):286-290, 2017.
- Redett RJ, Etra JW, Brandacher G, Burnett AL, Tuffaha SH, Sacks JM, Shores JT, Bivalacqua TJ, Bonawitz S, Cooney CM, Coon D, Pustavoitau A, Rizkalla NA, Jackson AM, Javia V, Fidder SAJ, Davis-Sproul J, Breenan DC, Sander IB, Shoham S, Sopko NA, Lee WPA, Cooney DS. Total Penis, Scrotum, and Lower Abdominal Wall Transplantation. N Engl J Med, 381(19):1876-1878m, 2019.
- Etra JW, Shores JT, Sander IB, Brandacher G, Lee WPA. Trauma-Induced Rejection in Vascularized Composite Allotransplantation. Ann Surg, 271(5);e113-114, 2020.
References
- "Dr. W. P. Andrew Lee selected EVP, Provost, and Dean to lead UT Southwestern's academic mission". www.utsouthwestern.edu. Retrieved 7 January 2020.
- "First total penis-scrotum transplant performed in US". Taipei Times. Agence France Presse. 25 April 2018. Retrieved 25 April 2018.
- Tsao, Nadia; Hsu, Stacy (5 March 2013). "Ex-Flying Tiger turns 102". Taipei Times. Retrieved 9 December 2018.
- Chung, Jake (11 December 2015). "Taiwan-born doctor to lead landmark penile transplant operations in US". Taipei Times. Retrieved 9 December 2018.
- "Johns Hopkins Alumnus W. P. Andrew Lee to Head Department of Plastic Surgery". Johns Hopkins University School of Medicine. 30 November 2010. Retrieved 25 April 2018.
- "Milton T. Edgerton, M.D. Professorship in Plastic & Reconstructive Surgery". Johns Hopkins University. Retrieved 25 April 2018.
- Grady, Denise (6 December 2015). "Penis Transplants Being Planned to Help Wounded Troops". The New York Times. ISSN 0362-4331. Retrieved 7 January 2020.
- Double-Arm Transplant Recipient: Feels Amazing, retrieved 2020-01-07
- Sgt Brendan Marrocco Letterman 2014 03 03 HQ, retrieved 2020-01-07
- Grady, Denise (23 April 2018). "'Whole Again': A Vet Maimed by an I.E.D. Receives a Transplanted Penis". New York Times. Retrieved 25 April 2018.
- Harris, Richard (23 April 2018). "Veteran Receives Penis Transplant To Repair War Wound". NPR. Retrieved 25 April 2018.
- Rosenberg, Eli (23 April 2018). "Veteran receives penis and scrotum transplant in surgery doctors say is a medical first". Washington Post. Retrieved 7 January 2020.