Valentina Greco

Valentina Greco is an Italian-born biologist who teaches at the Yale School of Medicine as the Carolyn Walch Slayman Professor of Genetics. Her research focuses on the role of skin stem cells in tissue regeneration.

Education

Greco received her undergraduate degree in Molecular Biology at the University of Palermo, Italy and received her PhD at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany working with Suzanne Eaton on tissue growth mechanisms.[1] She did her postdoctoral studies at Rockefeller University with Elaine Fuchs studying the mechanisms for stem cell activation during hair regeneration.[2]

Research

Greco's lab studies tissue maintenance and regeneration focusing on the stem cells in the skin hair follicle. Her lab uses techniques such as in vivo imaging to track individual stem cells over time and understand how these cells act during homeostasis and respond to tissue injury.[3] Her lab has worked extensively on the importance of the spatial organization of stem cell niches[4][5] and shown that these stem cells coordinate their differentiation and migration[6] and can clear away dead cells and tumor-like growths.[7]

Awards and Honors
  • National Institutes of Health Director's Pioneer Award (2019)[8]
  • Yale Mentoring Award in the Natural Sciences (2018)[1]
  • Class of ‘61 Award, Yale Cancer Center (2017)[1]
  • HHMI Faculty Scholar Award (2017)[9]
  • Glenn Award for Research in Biological Mechanisms of Aging (2017)[10]
  • Early Career Award, ASCB (2016)[11]
  • Edward Mallinckrodt, Jr. Foundation Scholar (2015)[12]
  • Robertson Stem Cell Investigator Award, New York Stem Cell Foundation (2015)[13]
  • Outstanding Young Investigator Award, ISSCR (2014)[14]
  • Dermatology Foundation Career Development Award (2012)[1]
  • American Skin Association Award (2011)[1]
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References
  1. "Valentina Greco, PhD". Yale School of Medicine. Retrieved 2019-10-19.
  2. Greco, Valentina; Chen, Ting; Rendl, Michael; Schober, Markus; Pasolli, H. Amalia; Stokes, Nicole; Cruz-Racelis, June dela; Fuchs, Elaine (2009-02-06). "A Two-Step Mechanism for Stem Cell Activation during Hair Regeneration". Cell Stem Cell. 4 (2): 155–169. doi:10.1016/j.stem.2008.12.009. ISSN 1934-5909. PMC 2668200. PMID 19200804.
  3. "Research". Greco Lab. Retrieved 2019-10-19.
  4. Rompolas, Panteleimon; Mesa, Kailin R.; Greco, Valentina (October 2013). "Spatial organization within a niche as a determinant of stem-cell fate". Nature. 502 (7472): 513–518. Bibcode:2013Natur.502..513R. doi:10.1038/nature12602. ISSN 1476-4687. PMC 3895444. PMID 24097351.
  5. Rompolas, Panteleimon; Mesa, Kailin R.; Kawaguchi, Kyogo; Park, Sangbum; Gonzalez, David; Brown, Samara; Boucher, Jonathan; Klein, Allon M.; Greco, Valentina (2016-06-17). "Spatiotemporal coordination of stem cell commitment during epidermal homeostasis". Science. 352 (6292): 1471–1474. Bibcode:2016Sci...352.1471R. doi:10.1126/science.aaf7012. ISSN 0036-8075. PMC 4958018. PMID 27229141.
  6. Park, Sangbum; Gonzalez, David G.; Guirao, Boris; Boucher, Jonathan D.; Cockburn, Katie; Marsh, Edward D.; Mesa, Kailin R.; Brown, Samara; Rompolas, Panteleimon; Haberman, Ann M.; Bellaïche, Yohanns (March 2017). "Tissue-scale coordination of cellular behaviour promotes epidermal wound repair in live mice". Nature Cell Biology. 19 (3): 155–163. doi:10.1038/ncb3472. ISSN 1476-4679. PMC 5581297. PMID 28248302.
  7. Pineda, Cristiana M.; Gonzalez, David G.; Matte-Martone, Catherine; Boucher, Jonathan; Lathrop, Elizabeth; Gallini, Sara; Fons, Nathan R.; Xin, Tianchi; Tai, Karen; Marsh, Edward; Nguyen, Don X. (2019-10-07). "Hair follicle regeneration suppresses Ras-driven oncogenic growth". The Journal of Cell Biology. 218 (10): 3212–3222. doi:10.1083/jcb.201907178. ISSN 0021-9525. PMID 31488583.
  8. Norman, Anita (2019-10-01). "Yale scientists win NIH awards for pioneering work". YaleNews. Retrieved 2019-10-19.
  9. "2016 Faculty Scholars". 2016 Faculty Scholars. Retrieved 2019-10-19.
  10. "Glenn Foundation for Medical Research Glenn Award for Research in Biological Mechanisms of Aging". glennfoundation.org. Retrieved 2019-10-19.
  11. "Valentina Greco and Bo Huang Win 2016 Early Career Award". ASCB. 2016-06-06. Retrieved 2019-10-19.
  12. "Current Awardees". emallinckrodtfoundation. Retrieved 2019-10-19.
  13. "NYSCF – Robertson Stem Cell Investigators Archives". New York Stem Cell Foundation. Retrieved 2019-10-19.
  14. "ISSCR Dr. Susan Lim Award for Outstanding Young Investigator". www.isscr.org. Retrieved 2019-10-19.
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