V-set and immunoglobulin domain containing 4

V-set and immunoglobulin domain containing 4 is a protein that in humans is encoded by the VSIG4 gene.[5]

VSIG4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2ICC, 2ICE, 2ICF
Identifiers
Aliases	VSIG4, CRIg, Z39IG, V-set and immunoglobulin domain containing 4
External IDs	OMIM: 300353 MGI: 2679720 HomoloGene: 48515 GeneCards: VSIG4
Gene location (Human) Chr. X chromosome (human)[1] Band Xq12 Start 66,021,738 bp[1] End 66,040,125 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X C3 Start 96,247,203 bp[2] End 96,293,438 bp[2]
Gene ontology Molecular function • GO:0001948 protein binding • complement component C3b binding Cellular component • integral component of membrane • membrane • macromolecular complex Biological process • innate immune system • Alternative complement pathway • immune system process • negative regulation of interleukin-2 production • negative regulation of T cell proliferation • negative regulation of macrophage activation • negative regulation of complement activation, alternative pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	11326	278180
Ensembl	ENSG00000155659	ENSMUSG00000044206
UniProt	Q9Y279	F6TUL9
RefSeq (mRNA)	NM_007268 NM_001100431 NM_001184830 NM_001184831 NM_001257403	NM_177789
RefSeq (protein)	NP_001093901 NP_001171759 NP_001171760 NP_001244332 NP_009199	NP_808457
Location (UCSC)	Chr X: 66.02 – 66.04 Mb	Chr X: 96.25 – 96.29 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a v-set and immunoglobulin-domain containing protein that is structurally related to the B7 family of immune regulatory proteins. The encoded protein may be a negative regulator of T-cell responses. This protein is also a receptor for the complement component 3 fragments C3b and iC3b. Alternate splicing results in multiple transcript variants.

References

1. GRCh38: Ensembl release 89: ENSG00000155659 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000044206 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: V-set and immunoglobulin domain containing 4". Retrieved 2016-06-13.

Further reading

• Helmy KY, Katschke KJ, Gorgani NN, Kljavin NM, Elliott JM, Diehl L, Scales SJ, Ghilardi N, van Lookeren Campagne M (2006). "CRIg: a macrophage complement receptor required for phagocytosis of circulating pathogens". Cell. 124 (5): 915–27. doi:10.1016/j.cell.2005.12.039. PMID 16530040.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.