VAV3

Guanine nucleotide exchange factor VAV3 is a protein that in humans is encoded by the VAV3 gene.[5]

VAV3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2D86
Identifiers
Aliases	VAV3, vav guanine nucleotide exchange factor 3
External IDs	OMIM: 605541 MGI: 1888518 HomoloGene: 38143 GeneCards: VAV3
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p13.3 Start 107,571,161 bp[1] End 107,965,180 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F3 Start 109,340,653 bp[2] End 109,685,698 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • metal ion binding • epidermal growth factor receptor binding • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity • Rac guanyl-nucleotide exchange factor activity • guanyl-nucleotide exchange factor activity • Rho guanyl-nucleotide exchange factor activity Cellular component • cytoplasm • cytosol • cell membrane Biological process • angiogenesis • Fc-gamma receptor signaling pathway involved in phagocytosis • GO:0007243 intracellular signal transduction • ephrin receptor signaling pathway • lamellipodium assembly • regulation of Rho protein signal transduction • positive regulation of phosphatidylinositol 3-kinase activity • vascular endothelial growth factor receptor signaling pathway • small GTPase mediated signal transduction • B cell receptor signaling pathway • cell projection assembly • Fc-epsilon receptor signaling pathway • positive regulation of apoptotic process • integrin-mediated signaling pathway • cellular response to DNA damage stimulus • regulation of cell size • regulation of small GTPase mediated signal transduction • cell migration • response to drug • platelet activation • vesicle fusion • positive regulation of cell adhesion • positive regulation of B cell proliferation • neutrophil chemotaxis • GO:0043087, GO:0032313, GO:0032319, GO:0032314, GO:0043088 regulation of GTPase activity • positive regulation of signal transduction • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10451	57257
Ensembl	ENSG00000134215	ENSMUSG00000033721
UniProt	Q9UKW4	Q9R0C8
RefSeq (mRNA)	NM_001079874 NM_006113	NM_020505 NM_146139 NM_001378987
RefSeq (protein)	NP_001073343 NP_006104	NP_065251 NP_666251 NP_001365916
Location (UCSC)	Chr 1: 107.57 – 107.97 Mb	Chr 3: 109.34 – 109.69 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[5]

Interactions

VAV3 has been shown to interact with Grb2.[6][7]

References

1. GRCh38: Ensembl release 89: ENSG00000134215 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033721 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: VAV3 vav 3 oncogene".
6. Blagoev, Blagoy; Kratchmarova Irina; Ong Shao-En; Nielsen Mogens; Foster Leonard J; Mann Matthias (March 2003). "A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling". Nat. Biotechnol. 21 (3): 315–318. doi:10.1038/nbt790. ISSN 1087-0156. PMID 12577067.
7. Zeng, L; Sachdev P; Yan L; Chan J L; Trenkle T; McClelland M; Welsh J; Wang L H (December 2000). "Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation". Mol. Cell. Biol. 20 (24): 9212–9224. doi:10.1128/MCB.20.24.9212-9224.2000. ISSN 0270-7306. PMC 102179. PMID 11094073.

Further reading

• Hobert O, Schilling JW, Beckerle MC, et al. (1996). "SH3 domain-dependent interaction of the proto-oncogene product Vav with the focal contact protein zyxin". Oncogene. 12 (7): 1577–81. PMID 8622875.
• Tamma SM, Chirmule N, Yagura H, et al. (1997). "CD4 cross-linking (CD4XL) induces RAS activation and tumor necrosis factor-alpha secretion in CD4+ T cells". Blood. 90 (4): 1588–93. PMID 9269777.
• Trenkle T, Welsh J, Jung B, et al. (1998). "Non-stoichiometric reduced complexity probes for cDNA arrays". Nucleic Acids Res. 26 (17): 3883–3891. doi:10.1093/nar/26.17.3883. PMC 147802. PMID 9705494.
• Movilla N, Bustelo XR (1999). "Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins". Mol. Cell. Biol. 19 (11): 7870–85. doi:10.1128/mcb.19.11.7870. PMC 84867. PMID 10523675.
• Trenkle T, McClelland M, Adlkofer K, Welsh J (2000). "Major transcript variants of VAV3, a new member of the VAV family of guanine nucleotide exchange factors". Gene. 245 (1): 139–149. doi:10.1016/S0378-1119(00)00026-3. PMID 10713454.
• Zeng L, Sachdev P, Yan L, et al. (2001). "Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation". Mol. Cell. Biol. 20 (24): 9212–9224. doi:10.1128/MCB.20.24.9212-9224.2000. PMC 102179. PMID 11094073.
• Inabe K, Ishiai M, Scharenberg AM, et al. (2002). "Vav3 modulates B cell receptor responses by regulating phosphoinositide 3-kinase activation". J. Exp. Med. 195 (2): 189–200. doi:10.1084/jem.20011571. PMC 2193613. PMID 11805146.
• Yabana N, Shibuya M (2002). "Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity". Oncogene. 21 (50): 7720–7729. doi:10.1038/sj.onc.1205927. PMID 12400014.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Zakaria S, Gomez TS, Savoy DN, et al. (2004). "Differential regulation of TCR-mediated gene transcription by Vav family members". J. Exp. Med. 199 (3): 429–434. doi:10.1084/jem.20031228. PMC 2211790. PMID 14757747.
• Pearce AC, Senis YA, Billadeau DD, et al. (2005). "Vav1 and vav3 have critical but redundant roles in mediating platelet activation by collagen". J. Biol. Chem. 279 (52): 53955–53962. doi:10.1074/jbc.M410355200. PMID 15456756.
• Charvet C, Canonigo AJ, Billadeau DD, Altman A (2005). "Membrane localization and function of Vav3 in T cells depend on its association with the adapter SLP-76". J. Biol. Chem. 280 (15): 15289–15299. doi:10.1074/jbc.M500275200. PMID 15708849.
• Lyons LS, Burnstein KL (2006). "Vav3, a Rho GTPase guanine nucleotide exchange factor, increases during progression to androgen independence in prostate cancer cells and potentiates androgen receptor transcriptional activity". Mol. Endocrinol. 20 (5): 1061–1072. doi:10.1210/me.2005-0346. PMID 16384856.
• Dong Z, Liu Y, Lu S, et al. (2006). "Vav3 oncogene is overexpressed and regulates cell growth and androgen receptor activity in human prostate cancer". Mol. Endocrinol. 20 (10): 2315–2325. doi:10.1210/me.2006-0048. PMID 16762975.