Ubiquitin-fold modifier conjugating enzyme 1
Ubiquitin-fold modifier conjugating enzyme 1 is a protein that in humans is encoded by the UFC1 gene. [5]
| UFC1 | |||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| |||||||||||||||||||||||||
| Identifiers | |||||||||||||||||||||||||
| Aliases | UFC1, HSPC155, ubiquitin-fold modifier conjugating enzyme 1, NEDSG | ||||||||||||||||||||||||
| External IDs | OMIM: 610554 MGI: 1913405 HomoloGene: 9500 GeneCards: UFC1 | ||||||||||||||||||||||||
| |||||||||||||||||||||||||
| |||||||||||||||||||||||||
| |||||||||||||||||||||||||
| Orthologs | |||||||||||||||||||||||||
| Species | Human | Mouse | |||||||||||||||||||||||
| Entrez | |||||||||||||||||||||||||
| Ensembl | |||||||||||||||||||||||||
| UniProt | |||||||||||||||||||||||||
| RefSeq (mRNA) | |||||||||||||||||||||||||
| RefSeq (protein) | |||||||||||||||||||||||||
| Location (UCSC) | Chr 1: 161.15 – 161.16 Mb | Chr 1: 171.29 – 171.3 Mb | |||||||||||||||||||||||
| PubMed search | [3] | [4] | |||||||||||||||||||||||
| Wikidata | |||||||||||||||||||||||||
| |||||||||||||||||||||||||
Function
UFC1 is an E2-like conjugating enzyme for ubiquitin-fold modifier-1 (UFM1; MIM 610553) (Komatsu et al., 2004 [PubMed 15071506]).[supplied by OMIM, Mar 2008].
gollark: FEAR inference.
gollark: Without detail or actual specific insults.
gollark: Alternatively, just tell someone you're insulting them.
gollark: No, too clear.
gollark: No, a *good* insult is nonsensical and not obviously an insult at all.
References
- GRCh38: Ensembl release 89: ENSG00000143222 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000062963 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Entrez Gene: Ubiquitin-fold modifier conjugating enzyme 1". Retrieved 2020-04-15.
Further reading
- Komatsu M, Chiba T, Tatsumi K, Iemura S, Tanida I, Okazaki N, Ueno T, Kominami E, Natsume T, Tanaka K (May 2004). "A novel protein-conjugating system for Ufm1, a ubiquitin-fold modifier". EMBO J. 23 (9): 1977–86. doi:10.1038/sj.emboj.7600205. PMC 404325. PMID 15071506.
- Liu G, Forouhar F, Eletsky A, Atreya HS, Aramini JM, Xiao R, Huang YJ, Abashidze M, Seetharaman J, Liu J, Rost B, Acton T, Montelione GT, Hunt JF, Szyperski T (April 2009). "NMR and X-RAY structures of human E2-like ubiquitin-fold modifier conjugating enzyme 1 (UFC1) reveal structural and functional conservation in the metazoan UFM1-UBA5-UFC1 ubiquination pathway". J. Struct. Funct. Genomics. 10 (2): 127–36. doi:10.1007/s10969-008-9054-7. PMC 2850604. PMID 19101823.
- Homrich M, Wobst H, Laurini C, Sabrowski J, Schmitz B, Diestel S (June 2014). "Cytoplasmic domain of NCAM140 interacts with ubiquitin-fold modifier-conjugating enzyme-1 (Ufc1)". Exp. Cell Res. 324 (2): 192–9. doi:10.1016/j.yexcr.2014.04.003. PMID 24726913.
- Xie S (August 2014). "Characterization, crystallization and preliminary X-ray crystallographic analysis of the human Uba5 C-terminus-Ufc1 complex". Acta Crystallogr F Struct Biol Commun. 70 (Pt 8): 1093–7. doi:10.1107/S2053230X14014502. PMC 4118812. PMID 25084390.
- Tellermann A, Witte T, Lansche C, Stoll M, Schmidt RE, Baerlecken NT (February 2015). "Autoantibodies binding to ubiquitin-fold modifier-conjugating enzyme 1 (Ufc1) and pleckstrin homology domain containing, family G (with RhoGef domain) member 2 (Plekhg2) are associated with mycobacterial infections". HIV Med. 16 (2): 114–21. doi:10.1111/hiv.12194. PMID 25213431.
- Cao C, Sun J, Zhang D, Guo X, Xie L, Li X, Wu D, Liu L (February 2015). "The long intergenic noncoding RNA UFC1, a target of MicroRNA 34a, interacts with the mRNA stabilizing protein HuR to increase levels of β-catenin in HCC cells". Gastroenterology. 148 (2): 415–26.e18. doi:10.1053/j.gastro.2014.10.012. PMID 25449213.
- Zhang G, Wu Y, Xu D, Yan X (November 2016). "Long Noncoding RNA UFC1 Promotes Proliferation of Chondrocyte in Osteoarthritis by Acting as a Sponge for miR-34a". DNA Cell Biol. 35 (11): 691–695. doi:10.1089/dna.2016.3397. PMID 27529373.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.