Ubiquilin 4

UBQLN4
Identifiers
Aliases	UBQLN4, A1U, A1Up, C1orf6, CIP75, UBIN, Ubiquilin 4
External IDs	OMIM: 605440 MGI: 2150152 HomoloGene: 41346 GeneCards: UBQLN4
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	156,053,798 bp[1]
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)[2]
End	88,569,725 bp[2]
Gene ontology
Molecular function	• polyubiquitin modification-dependent protein binding; • GO:0001948 protein binding; • identical protein binding;
Cellular component	• cytoplasm; • perinuclear region of cytoplasm; • autophagosome; • nuclear proteasome complex; • cytosolic proteasome complex; • cytosol; • endoplasmic reticulum membrane; • cytoplasmic vesicle; • endoplasmic reticulum; • cell nucleus; • chromosome; • site of DNA damage;
Biological process	• autophagy; • negative regulation of autophagosome maturation; • regulation of proteasomal ubiquitin-dependent protein catabolic process; • ubiquitin-dependent protein catabolic process; • DNA repair; • cellular response to DNA damage stimulus; • negative regulation of double-strand break repair via homologous recombination;
	Sources:Amigo / QuickGO
Orthologs
	56893
	94232
	ENSG00000160803
	ENSMUSG00000008604
	Q9NRR5
	Q99NB8
	NM_001304342; NM_020131
	NM_033526
	NP_001291271; NP_064516
	NP_277068
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquilin 4 is a protein in humans that is encoded by the UBQLN4 gene.[5][6][7] Ubiquilin 4 regulates proteasomal protein degradation.[8]

Similarity to Other Proteins

Human UBQLN4 shares a high degree of similarity with related ubiquilins including UBQLN1 and UBQLN2.[9]

gollark: <@148221133332807681> Have you heard of Linux?

gollark: Support for `b` has been added.

gollark: Hold on, that will be patched in v6.12468.

gollark: - All this useless random junk can autoupdate (this is probably a backdoor)!- EZCopy allows you to easily install potatOS on another device, just by sticking it in the disk drive of any potatOS device!- fs.load and fs.dump - probably helpful somehow.- Blocks bad programs (like the "Webicity" browser).- Fully-featured process manager.- Can run in "hidden mode" where it's at least not obvious at a glance that potatOS is installed.- Convenient, simple uninstall with the "uninstall" command.- Turns on any networked potatOS computers!- Edits connected signs to use as ad displays.- A recycle bin.- An exorcise command, which is like delete but better.- Support for a wide variety of Lorem Ipsum.

gollark: Best viewed in Internet Explorer 6.00000000000004 running on a Difference Engine emulated under MacOS 7 on a Pentium 3. Features:- Fortunes/Dwarf Fortress output/Chuck Norris jokes on boot (wait, IS this a feature?)- (other) viruses (how do you get them in the first place? running random files like this?) cannot do anything particularly awful to your computer - uninterceptable (except by crashing the keyboard shortcut daemon, I guess) keyboard shortcuts allow easy wiping of the non-potatOS data so you can get back to whatever nonsense you do fast- Skynet (rednet-ish stuff over websocket to my server) and Lolcrypt (encoding data as lols and punctuation) built in for easy access!- Convenient OS-y APIs - add keyboard shortcuts, spawn background processes & do "multithreading"-ish stuff.- Great features for other idio- OS designers, like passwords and fake loading (est potatOS.stupidity.loading [time], est potatOS.stupidity.password [password]).- Digits of Tau available via a convenient command ("tau")- Potatoplex and Loading built in ("potatoplex"/"loading") (potatoplex has many undocumented options)!- Stack traces (yes, I did steal them from MBS)- Backdoors- er, remote debugging access (it's secured, via ECC signing on disks and websocket-only access requiring a key for the other one)

References

GRCh38: Ensembl release 89: ENSG00000160803 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000008604 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: Ubiquilin 4". Retrieved 2013-06-27.
Davidson JD, Riley B, Burright EN, Duvick LA, Zoghbi HY, Orr HT (September 2000). "Identification and characterization of an ataxin-1-interacting protein: A1Up, a ubiquitin-like nuclear protein". Hum. Mol. Genet. 9 (15): 2305–12. doi:10.1093/oxfordjournals.hmg.a018922. PMID 11001934.
Matsuda M, Koide T, Yorihuzi T, Hosokawa N, Nagata K (January 2001). "Molecular cloning of a novel ubiquitin-like protein, UBIN, that binds to ER targeting signal sequences". Biochem. Biophys. Res. Commun. 280 (2): 535–40. doi:10.1006/bbrc.2000.4149. PMID 11162551.
Riley BE, Xu Y, Zoghbi HY, Orr HT (October 2004). "The effects of the polyglutamine repeat protein ataxin-1 on the UbL-UBA protein A1Up". J. Biol. Chem. 279 (40): 42290–301. doi:10.1074/jbc.M406284200. PMID 15280365.
Marín I (March 2014). "The ubiquilin gene family: evolutionary patterns and functional insights". BMC Evol Biol. 14: 63. doi:10.1186/1471-2148-14-63. PMC 4230246. PMID 24674348.

External links

UBQLN4 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000160803 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000008604 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Ubiquilin 4". Retrieved 2013-06-27.

[pmid11001934-6] Davidson JD, Riley B, Burright EN, Duvick LA, Zoghbi HY, Orr HT (September 2000). "Identification and characterization of an ataxin-1-interacting protein: A1Up, a ubiquitin-like nuclear protein". Hum. Mol. Genet. 9 (15): 2305–12. doi:10.1093/oxfordjournals.hmg.a018922. PMID 11001934.

[pmid11162551-7] Matsuda M, Koide T, Yorihuzi T, Hosokawa N, Nagata K (January 2001). "Molecular cloning of a novel ubiquitin-like protein, UBIN, that binds to ER targeting signal sequences". Biochem. Biophys. Res. Commun. 280 (2): 535–40. doi:10.1006/bbrc.2000.4149. PMID 11162551.

[pmid15280365-8] Riley BE, Xu Y, Zoghbi HY, Orr HT (October 2004). "The effects of the polyglutamine repeat protein ataxin-1 on the UbL-UBA protein A1Up". J. Biol. Chem. 279 (40): 42290–301. doi:10.1074/jbc.M406284200. PMID 15280365.

[pmid24674348-9] Marín I (March 2014). "The ubiquilin gene family: evolutionary patterns and functional insights". BMC Evol Biol. 14: 63. doi:10.1186/1471-2148-14-63. PMC 4230246. PMID 24674348.