USP8

Ubiquitin carboxyl-terminal hydrolase 8 is an enzyme that in humans is encoded by the USP8 gene.[5][6][7]

USP8
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesUSP8, HumORF8, SPG59, UBPY, ubiquitin specific peptidase 8, PITA4
External IDsOMIM: 603158 MGI: 1934029 HomoloGene: 3782 GeneCards: USP8
Gene location (Human)
Chr.Chromosome 15 (human)[1]
Band15q21.2Start50,424,380 bp[1]
End50,514,421 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

9101

84092

Ensembl

ENSG00000138592

ENSMUSG00000027363

UniProt

P40818

Q80U87

RefSeq (mRNA)

NM_001128610
NM_001128611
NM_001283049
NM_005154

NM_001252580
NM_019729

RefSeq (protein)

NP_001122082
NP_001269978
NP_005145

NP_001239509
NP_062703

Location (UCSC)Chr 15: 50.42 – 50.51 MbChr 2: 126.71 – 126.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

USP8 has been shown to interact with RNF41[8] and STAM2.[9][10]

gollark: Won't work how?
gollark: I think what would also work is the ingot recipe being a factor of 16000 instead of something stupid.
gollark: OC has fluidy whatevers?
gollark: I could, alternatively, give each melter a dedicated former and enforce the ore-supplied-in-pairs thing.
gollark: Maybe if I just *automatically* clean them out it'd be better.

References

  1. GRCh38: Ensembl release 89: ENSG00000138592 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000027363 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (July 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346.
  6. Janssen JW, Schleithoff L, Bartram CR, Schulz AS (May 1998). "An oncogenic fusion product of the phosphatidylinositol 3-kinase p85beta subunit and HUMORF8, a putative deubiquitinating enzyme". Oncogene. 16 (13): 1767–72. doi:10.1038/sj.onc.1201695. PMID 9582025.
  7. "Entrez Gene: USP8 ubiquitin specific peptidase 8".
  8. Wu, Xiuli; Yen Lily; Irwin Lisa; Sweeney Colleen; Carraway Kermit L (September 2004). "Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8". Mol. Cell. Biol. 24 (17): 7748–57. doi:10.1128/MCB.24.17.7748-7757.2004. ISSN 0270-7306. PMC 506982. PMID 15314180.
  9. Kaneko, Tomonori; Kumasaka Takashi; Ganbe Tadashi; Sato Takao; Miyazawa Keiji; Kitamura Naomi; Tanaka Nobuo (November 2003). "Structural insight into modest binding of a non-PXXP ligand to the signal transducing adaptor molecule-2 Src homology 3 domain". J. Biol. Chem. 278 (48): 48162–8. doi:10.1074/jbc.M306677200. ISSN 0021-9258. PMID 13129930.
  10. Kato, M; Miyazawa K; Kitamura N (December 2000). "A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP". J. Biol. Chem. 275 (48): 37481–7. doi:10.1074/jbc.M007251200. ISSN 0021-9258. PMID 10982817.

Further reading

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.