USP42

Ubiquitin carboxyl-terminal hydrolase 42 is an enzyme that in humans is encoded by the USP42 gene.[5][6]

USP42
Identifiers
Aliases	USP42, ubiquitin specific peptidase 42
External IDs	MGI: 1924050 HomoloGene: 35425 GeneCards: USP42
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p22.1 Start 6,104,884 bp[1] End 6,161,564 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 G2|5 82.5 cM Start 143,710,325 bp[2] End 143,732,280 bp[2]
Gene ontology Molecular function • cysteine-type peptidase activity • GO:0001948 protein binding • peptidase activity • hydrolase activity • thiol-dependent ubiquitin-specific protease activity • thiol-dependent ubiquitinyl hydrolase activity • cysteine-type endopeptidase activity Cellular component • nucleoplasm Biological process • ubiquitin-dependent protein catabolic process • spermatogenesis • proteolysis • cell differentiation • protein deubiquitination • regulation of apoptotic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	84132	76800
Ensembl	ENSG00000106346	ENSMUSG00000051306
UniProt	Q9H9J4	B2RQC2
RefSeq (mRNA)	NM_032172 NM_001365764	NM_029749
RefSeq (protein)	NP_115548 NP_001352693	NP_084025
Location (UCSC)	Chr 7: 6.1 – 6.16 Mb	Chr 5: 143.71 – 143.73 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000106346 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000051306 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346.
6. "Entrez Gene: USP42 ubiquitin specific peptidase 42".

Further reading

• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Quesada V, Díaz-Perales A, Gutiérrez-Fernández A, et al. (2004). "Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases". Biochem. Biophys. Res. Commun. 314 (1): 54–62. doi:10.1016/j.bbrc.2003.12.050. PMID 14715245.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.