USP40

Ubiquitin carboxyl-terminal hydrolase 40 is an enzyme that in humans is encoded by the USP40 gene.[5][6]

USP40
Identifiers
Aliases	USP40, ubiquitin specific peptidase 40
External IDs	OMIM: 610570 MGI: 2443184 HomoloGene: 32400 GeneCards: USP40
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q37.1 Start 233,475,520 bp[1] End 233,566,782 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 D Start 87,945,119 bp[2] End 88,008,551 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • thiol-dependent ubiquitinyl hydrolase activity • peptidase activity • cysteine-type peptidase activity • hydrolase activity • cysteine-type endopeptidase activity • thiol-dependent ubiquitin-specific protease activity Cellular component • cytoplasm • cell nucleus • cytosol Biological process • protein deubiquitination • ubiquitin-dependent protein catabolic process • proteolysis • regulation of protein stability Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55230	227334
Ensembl	ENSG00000085982	ENSMUSG00000005501
UniProt	Q9NVE5	Q8BWR4
RefSeq (mRNA)	NM_018218 NM_001365479	NM_001033291 NM_001198573
RefSeq (protein)	NP_060688 NP_001352408 NP_001369224 NP_001369225 NP_001369226 NP_001369227 NP_001369228 NP_001369229 NP_001369230 NP_001369231 NP_001369232	NP_001028463 NP_001185502
Location (UCSC)	Chr 2: 233.48 – 233.57 Mb	Chr 1: 87.95 – 88.01 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000085982 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000005501 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346.
6. "Entrez Gene: USP40 ubiquitin specific peptidase 40".

Further reading

• Bass BL (2002). "RNA editing by adenosine deaminases that act on RNA". Annu. Rev. Biochem. 71 (1): 817–46. doi:10.1146/annurev.biochem.71.110601.135501. PMC 1823043. PMID 12045112.
• Chen X, Zhang Y, Douglas L, Zhou P (2002). "UV-damaged DNA-binding proteins are targets of CUL-4A-mediated ubiquitination and degradation". J. Biol. Chem. 276 (51): 48175–82. doi:10.1074/jbc.M106808200. PMID 11673459.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Quesada V, Díaz-Perales A, Gutiérrez-Fernández A, et al. (2004). "Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases". Biochem. Biophys. Res. Commun. 314 (1): 54–62. doi:10.1016/j.bbrc.2003.12.050. PMID 14715245.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
• Li Y, Schrodi S, Rowland C, et al. (2006). "Genetic evidence for ubiquitin-specific proteases USP24 and USP40 as candidate genes for late-onset Parkinson disease". Hum. Mutat. 27 (10): 1017–23. doi:10.1002/humu.20382. PMID 16917932.