USP39

U4/U6.U5 tri-snRNP-associated protein 2 is a protein that in humans is encoded by the USP39 gene.[4][5]

USP39
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3JCR
Identifiers
Aliases	USP39, 65K, HSPC332, SAD1, SNRNP65, CGI-21, ubiquitin specific peptidase 39
External IDs	OMIM: 611594 MGI: 107622 HomoloGene: 13183 GeneCards: USP39
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p11.2 Start 85,602,856 bp[1] End 85,649,283 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • thiol-dependent ubiquitinyl hydrolase activity • zinc ion binding • metal ion binding • GO:0001948 protein binding Cellular component • spliceosomal complex • cell nucleus • nucleoplasm • U4/U6 x U5 tri-snRNP complex Biological process • protein deubiquitination • mRNA splicing, via spliceosome • cell cycle • mRNA processing • RNA splicing • cell division • spliceosomal complex assembly Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10713	28035
Ensembl	ENSG00000168883	n/a
UniProt	Q53GS9	Q3TIX9
RefSeq (mRNA)	NM_001256725 NM_001256726 NM_001256727 NM_001256728 NM_006590	NM_138592
RefSeq (protein)	NP_001243654 NP_001243655 NP_001243656 NP_001243657 NP_006581	NP_613058
Location (UCSC)	Chr 2: 85.6 – 85.65 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000168883 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–558. doi:10.1038/nrg1111. PMID 12838346.
5. "Entrez Gene: USP39 ubiquitin specific peptidase 39".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Lygerou Z, Christophides G, Séraphin B (1999). "A novel genetic screen for snRNP assembly factors in yeast identifies a conserved protein, Sad1p, also required for pre-mRNA splicing". Mol. Cell. Biol. 19 (3): 2008–20. PMC 83994. PMID 10022888.
• Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–713. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
• Makarova OV, Makarov EM, Lührmann R (2001). "The 65 and 110 kDa SR-related proteins of the U4/U6.U5 tri-snRNP are essential for the assembly of mature spliceosomes". EMBO J. 20 (10): 2553–2563. doi:10.1093/emboj/20.10.2553. PMC 125249. PMID 11350945.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.