UPP1

Uridine phosphorylase 1 is an enzyme that in humans is encoded by the UPP1 gene.[5][6][7]

UPP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3EUE, 3EUF, 3NBQ
Identifiers
Aliases	UPP1, UDRPASE, UP, UPASE, UPP, uridine phosphorylase 1
External IDs	OMIM: 191730 MGI: 1097668 HomoloGene: 2524 GeneCards: UPP1
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p12.3 Start 48,088,628 bp[1] End 48,108,736 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 A1 Start 9,118,103 bp[2] End 9,136,170 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • catalytic activity • transferase activity, transferring pentosyl groups • transferase activity, transferring glycosyl groups • uridine phosphorylase activity Cellular component • cytoplasm • cytosol • cell nucleus • nucleoplasm Biological process • pyrimidine nucleoside salvage • pyrimidine nucleotide metabolic process • nucleoside metabolic process • uridine metabolic process • nucleotide catabolic process • cellular response to glucose starvation • nucleobase-containing compound metabolic process • pyrimidine nucleoside catabolic process • UMP salvage • uridine catabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7378	22271
Ensembl	ENSG00000183696	ENSMUSG00000020407
UniProt	Q16831	P52624
RefSeq (mRNA)	NM_001287426 NM_001287428 NM_001287429 NM_001287430 NM_003364 NM_181597 NM_001362774	NM_001159401 NM_001159402 NM_009477
RefSeq (protein)	NP_001274355 NP_001274357 NP_001274358 NP_001274359 NP_003355 NP_001349703	NP_001152873 NP_001152874 NP_033503
Location (UCSC)	Chr 7: 48.09 – 48.11 Mb	Chr 11: 9.12 – 9.14 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

UPP1 has been shown to interact with Vimentin.[8]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.[§ 1]

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|{{{bSize}}}px|alt=Fluorouracil (5-FU) Activity edit]]

Fluorouracil (5-FU) Activity edit

1. The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".

References

1. GRCh38: Ensembl release 89: ENSG00000183696 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020407 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Denney RM, Nichols EA, Ruddle FH (September 1979). "Assignment of a gene for uridine phosphorylase to chromosome 7". Cytogenet Cell Genet. 22 (1–6): 195–9. doi:10.1159/000130934. PMID 752472.
6. Kanzaki A, Takebayashi Y, Bando H, Eliason JF, Watanabe Si S, Miyashita H, Fukumoto M, Toi M, Uchida T (January 2002). "Expression of uridine and thymidine phosphorylase genes in human breast carcinoma". Int J Cancer. 97 (5): 631–5. doi:10.1002/ijc.10105. PMID 11807789.
7. "Entrez Gene: UPP1 uridine phosphorylase 1".
8. Russell, R L; Cao D; Zhang D; Handschumacher R E; Pizzorno G (April 2001). "Uridine phosphorylase association with vimentin. Intracellular distribution and localization". J. Biol. Chem. United States. 276 (16): 13302–7. doi:10.1074/jbc.M008512200. ISSN 0021-9258. PMID 11278417.

Further reading

• Pizzorno G, Cao D, Leffert JJ, et al. (2002). "Homeostatic control of uridine and the role of uridine phosphorylase: a biological and clinical update". Biochim. Biophys. Acta. 1587 (2–3): 133–44. doi:10.1016/s0925-4439(02)00076-5. PMID 12084455.
• Watanabe S, Uchida T (1995). "Cloning and expression of human uridine phosphorylase". Biochem. Biophys. Res. Commun. 216 (1): 265–72. doi:10.1006/bbrc.1995.2619. PMID 7488099.
• Russell RL, Cao D, Zhang D, et al. (2001). "Uridine phosphorylase association with vimentin. Intracellular distribution and localization". J. Biol. Chem. 276 (16): 13302–7. doi:10.1074/jbc.M008512200. PMID 11278417.
• Miyashita H, Takebayashi Y, Eliason JF, et al. (2002). "Uridine phosphorylase is a potential prognostic factor in patients with oral squamous cell carcinoma". Cancer. 94 (11): 2959–66. doi:10.1002/cncr.10568. PMID 12115385.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Temmink OH, de Bruin M, Laan AC, et al. (2006). "The role of thymidine phosphorylase and uridine phosphorylase in (fluoro)pyrimidine metabolism in peripheral blood mononuclear cells". Int. J. Biochem. Cell Biol. 38 (10): 1759–65. doi:10.1016/j.biocel.2006.04.007. PMID 16798057.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Uridine phosphorylase 1 (UPP1)