UPK3A

Uroplakin-3a is a protein that in humans is encoded by the UPK3A gene.[5][6]

UPK3A
Identifiers
Aliases	UPK3A, UP3A, UPIII, UPIIIA, UPK3, uroplakin 3A
External IDs	OMIM: 611559 MGI: 98914 HomoloGene: 5066 GeneCards: UPK3A
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.31 Start 45,284,949 bp[1] End 45,295,874 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 E2 Start 85,017,141 bp[2] End 85,022,547 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • extracellular exosome • endoplasmic reticulum membrane • apical plasma membrane • membrane • integral component of membrane • endoplasmic reticulum • apical plasma membrane urothelial plaque Biological process • kidney development • urea transport • epithelial cell differentiation • sodium ion homeostasis • potassium ion homeostasis • urinary bladder development • cell morphogenesis • water transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7380	22270
Ensembl	ENSG00000100373	ENSMUSG00000022435
UniProt	O75631	Q9JKX8
RefSeq (mRNA)	NM_001167574 NM_006953	NM_023478
RefSeq (protein)	NP_001161046 NP_008884	NP_075967
Location (UCSC)	Chr 22: 45.28 – 45.3 Mb	Chr 15: 85.02 – 85.02 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

It is found in the inner membrane of the urinary bladder and contributes to the strength of that membrane and to the membrane's ability to stretch when the bladder is full.[7] It is also found in the renal pelvis, ureter, and prostatic urethra.

References

1. GRCh38: Ensembl release 89: ENSG00000100373 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022435 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yuasa T, Yoshiki T, Tanaka T, Kim CJ, Isono T, Okada Y (Dec 1998). "Expression of uroplakin Ib and uroplakin III genes in tissues and peripheral blood of patients with transitional cell carcinoma". Jpn J Cancer Res. 89 (9): 879–82. doi:10.1111/j.1349-7006.1998.tb00643.x. PMC 5921953. PMID 9818021.
6. "Entrez Gene: UPK3A uroplakin 3A".
7. Wu XR, Kong XP, Pellicer A, Kreibich G, Sun TT (2009). "Uroplakins in urothelial biology, function, and disease". Kidney Int. 75: 1153–65. doi:10.1038/ki.2009.73. PMC 3717210. PMID 19340092.

Further reading

• Wu XR, Sun TT (1994). "Molecular cloning of a 47 kDa tissue-specific and differentiation-dependent urothelial cell surface glycoprotein". J. Cell Sci. 106 (1): 31–43. PMID 8270634.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Lobban ED, Smith BA, Hall GD, et al. (1998). "Uroplakin gene expression by normal and neoplastic human urothelium". Am. J. Pathol. 153 (6): 1957–67. doi:10.1016/S0002-9440(10)65709-4. PMC 1866332. PMID 9846985.
• Ogawa K, Johansson SL, Cohen SM (1999). "Immunohistochemical analysis of uroplakins, urothelial specific proteins, in ovarian Brenner tumors, normal tissues, and benign and neoplastic lesions of the female genital tract". Am. J. Pathol. 155 (4): 1047–50. doi:10.1016/S0002-9440(10)65206-6. PMC 1867018. PMID 10514386.
• Olsburgh J, Harnden P, Weeks R, et al. (2003). "Uroplakin gene expression in normal human tissues and locally advanced bladder cancer". J. Pathol. 199 (1): 41–9. doi:10.1002/path.1252. PMID 12474225.
• Tu L, Sun TT, Kreibich G (2003). "Specific heterodimer formation is a prerequisite for uroplakins to exit from the endoplasmic reticulum". Mol. Biol. Cell. 13 (12): 4221–30. doi:10.1091/mbc.E02-04-0211. PMC 138628. PMID 12475947.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Koga F, Kawakami S, Fujii Y, et al. (2004). "Impaired p63 expression associates with poor prognosis and uroplakin III expression in invasive urothelial carcinoma of the bladder". Clin. Cancer Res. 9 (15): 5501–7. PMID 14654529.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Schönfelder EM, Knüppel T, Tasic V, et al. (2006). "Mutations in Uroplakin IIIA are a rare cause of renal hypodysplasia in humans". Am. J. Kidney Dis. 47 (6): 1004–12. doi:10.1053/j.ajkd.2006.02.177. PMID 16731295.
• Zeng Y, Wu XX, Homma Y, et al. (2007). "Uroplakin III-delta4 messenger RNA as a promising marker to identify nonulcerative interstitial cystitis". J. Urol. 178 (4 Pt 1): 1322–7, discussion 1327. doi:10.1016/j.juro.2007.05.125. PMID 17698128.