UPK3A

Uroplakin-3a is a protein that in humans is encoded by the UPK3A gene.[5][6]

UPK3A
Identifiers
AliasesUPK3A, UP3A, UPIII, UPIIIA, UPK3, uroplakin 3A
External IDsOMIM: 611559 MGI: 98914 HomoloGene: 5066 GeneCards: UPK3A
Gene location (Human)
Chr.Chromosome 22 (human)[1]
Band22q13.31Start45,284,949 bp[1]
End45,295,874 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

7380

22270

Ensembl

ENSG00000100373

ENSMUSG00000022435

UniProt

O75631

Q9JKX8

RefSeq (mRNA)

NM_001167574
NM_006953

NM_023478

RefSeq (protein)

NP_001161046
NP_008884

NP_075967

Location (UCSC)Chr 22: 45.28 – 45.3 MbChr 15: 85.02 – 85.02 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

It is found in the inner membrane of the urinary bladder and contributes to the strength of that membrane and to the membrane's ability to stretch when the bladder is full.[7] It is also found in the renal pelvis, ureter, and prostatic urethra.


References

  1. GRCh38: Ensembl release 89: ENSG00000100373 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000022435 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Yuasa T, Yoshiki T, Tanaka T, Kim CJ, Isono T, Okada Y (Dec 1998). "Expression of uroplakin Ib and uroplakin III genes in tissues and peripheral blood of patients with transitional cell carcinoma". Jpn J Cancer Res. 89 (9): 879–82. doi:10.1111/j.1349-7006.1998.tb00643.x. PMC 5921953. PMID 9818021.
  6. "Entrez Gene: UPK3A uroplakin 3A".
  7. Wu XR, Kong XP, Pellicer A, Kreibich G, Sun TT (2009). "Uroplakins in urothelial biology, function, and disease". Kidney Int. 75: 1153–65. doi:10.1038/ki.2009.73. PMC 3717210. PMID 19340092.

Further reading


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