UNC93A

Unc-93 homolog A (C. elegans) is a protein that in humans is encoded by the UNC93A gene.[5]

UNC93A
Identifiers
Aliases	UNC93A, Unc-93A, dJ366N23.1, dJ366N23.2, UNC93A (gene), unc-93 homolog A (C. elegans), unc-93 homolog A
External IDs	OMIM: 607995 MGI: 1933250 HomoloGene: 10356 GeneCards: UNC93A
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q27 Start 167,271,169 bp[1] End 167,316,014 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 A1|17 8.78 cM Start 13,108,617 bp[2] End 13,131,810 bp[2]
Gene ontology Molecular function • molecular function Cellular component • membrane • integral component of membrane • cell membrane Biological process • biological process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	54346	381058
Ensembl	ENSG00000112494	ENSMUSG00000067049
UniProt	Q86WB7	Q710D3
RefSeq (mRNA)	NM_001143947 NM_018974	NM_199252
RefSeq (protein)	NP_001137419 NP_061847	NP_954860
Location (UCSC)	Chr 6: 167.27 – 167.32 Mb	Chr 17: 13.11 – 13.13 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Unc93A is a major facilitator superfamily (MFS), and a putative solute carrier in humans.[6][7] It belongs to the atypical SLCs that was recently listed.[6] It is therefore presumed that UNC93A is a transporter protein.

UNC93A is closely related to UNC93B1 and MFSD11.[8][9]

UNC93A is affected by amino acid deprivation in cell cortex cultures[7][8] and starvation in in vivo samples.[8]

It is expressed in neurons, with staining close to the plasma membrane.[8]

Read also [10][11] for functional studies in C.elegans.

References

1. GRCh38: Ensembl release 89: ENSG00000112494 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000067049 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Unc-93 homolog A (C. elegans)".
6. Perland E, Fredriksson R (March 2017). "Classification Systems of Secondary Active Transporters". Trends in Pharmacological Sciences. 38 (3): 305–315. doi:10.1016/j.tips.2016.11.008. PMID 27939446.
7. Perland E, Bagchi S, Klaesson A, Fredriksson R (September 2017). "Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression". Open Biology. 7 (9): 170142. doi:10.1098/rsob.170142. PMC 5627054. PMID 28878041.
8. Ceder MM, Lekholm E, Hellsten SV, Perland E, Fredriksson R (2017). "The Neuronal and Peripheral Expressed Membrane-Bound UNC93A Respond to Nutrient Availability in Mice". Frontiers in Molecular Neuroscience. 10: 351. doi:10.3389/fnmol.2017.00351. PMC 5671512. PMID 29163028.
9. Perland E, Lekholm E, Eriksson MM, Bagchi S, Arapi V, Fredriksson R (2016). "The Putative SLC Transporters Mfsd5 and Mfsd11 Are Abundantly Expressed in the Mouse Brain and Have a Potential Role in Energy Homeostasis". PLOS ONE. 11 (6): e0156912. Bibcode:2016PLoSO..1156912P. doi:10.1371/journal.pone.0156912. PMC 4896477. PMID 27272503.
10. Levin JZ, Horvitz HR (April 1992). "The Caenorhabditis elegans unc-93 gene encodes a putative transmembrane protein that regulates muscle contraction". The Journal of Cell Biology. 117 (1): 143–55. doi:10.1083/jcb.117.1.143. PMC 2289394. PMID 1313436.
11. de la Cruz IP, Levin JZ, Cummins C, Anderson P, Horvitz HR (October 2003). "sup-9, sup-10, and unc-93 may encode components of a two-pore K+ channel that coordinates muscle contraction in Caenorhabditis elegans". The Journal of Neuroscience. 23 (27): 9133–45. doi:10.1523/JNEUROSCI.23-27-09133.2003. PMC 6740817. PMID 14534247.

Further reading

• Liu Y, Dodds P, Emilion G, Mungall AJ, Dunham I, Beck S, Wells RS, Charnock FM, Ganesan TS (October 2002). "The human homologue of unc-93 maps to chromosome 6q27 - characterisation and analysis in sporadic epithelial ovarian cancer". BMC Genetics. 3: 20. doi:10.1186/1471-2156-3-20. PMC 134458. PMID 12381271.