UNC5A

Netrin receptor UNC5A is a protein that in humans is encoded by the UNC5A gene.[5]

UNC5A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4V2A
Identifiers
Aliases	UNC5A, UNC5H1, unc-5 netrin receptor A
External IDs	OMIM: 607869 MGI: 894682 HomoloGene: 41474 GeneCards: UNC5A
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q35.2 Start 176,810,519 bp[1] End 176,880,898 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 B1 Start 54,949,411 bp[2] End 55,006,018 bp[2]
Gene ontology Molecular function • netrin receptor activity Cellular component • intrinsic component of plasma membrane • integral component of membrane • neuronal cell body membrane • membrane raft • cell membrane • cell projection • neuron projection membrane • membrane Biological process • multicellular organism development • neuron projection development • signal transduction • anterior/posterior axon guidance • axon guidance • apoptotic process • netrin-activated signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	90249	107448
Ensembl	ENSG00000113763	ENSMUSG00000025876
UniProt	Q6ZN44	Q8K1S4
RefSeq (mRNA)	NM_133369	NM_153131 NM_001311128
RefSeq (protein)	NP_588610	NP_001298057 NP_694771
Location (UCSC)	Chr 5: 176.81 – 176.88 Mb	Chr 13: 54.95 – 55.01 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

UNC5A belongs to a family of netrin-1 (MIM 601614) receptors thought to mediate the chemorepulsive effect of netrin-1 on specific axons. For more information on UNC5 proteins, see UNC5C (MIM 603610).[supplied by OMIM][5]

Interactions

UNC5A has been shown to interact with MAGED1.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000113763 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025876 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: UNC5A unc-5 homolog A (C. elegans)".
6. Williams ME, Strickland P, Watanabe K, Hinck L (May 2003). "UNC5H1 induces apoptosis via its juxtamembrane region through an interaction with NRAGE". The Journal of Biological Chemistry. 278 (19): 17483–90. doi:10.1074/jbc.M300415200. PMID 12598531.

Further reading

• Arakawa H (December 2004). "Netrin-1 and its receptors in tumorigenesis". Nature Reviews. Cancer. 4 (12): 978–87. doi:10.1038/nrc1504. PMID 15573119.
• Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Nagase T, Kikuno R, Ohara O (December 2001). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins". DNA Research. 8 (6): 319–27. doi:10.1093/dnares/8.6.319. PMID 11853319.
• Williams ME, Strickland P, Watanabe K, Hinck L (May 2003). "UNC5H1 induces apoptosis via its juxtamembrane region through an interaction with NRAGE". The Journal of Biological Chemistry. 278 (19): 17483–90. doi:10.1074/jbc.M300415200. PMID 12598531.
• Tanikawa C, Matsuda K, Fukuda S, Nakamura Y, Arakawa H (March 2003). "p53RDL1 regulates p53-dependent apoptosis". Nature Cell Biology. 5 (3): 216–23. doi:10.1038/ncb943. PMID 12598906.
• Thiebault K, Mazelin L, Pays L, Llambi F, Joly MO, Scoazec JY, et al. (April 2003). "The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment". Proceedings of the National Academy of Sciences of the United States of America. 100 (7): 4173–8. Bibcode:2003PNAS..100.4173T. doi:10.1073/pnas.0738063100. PMC 153067. PMID 12655055.
• Geisbrecht BV, Dowd KA, Barfield RW, Longo PA, Leahy DJ (August 2003). "Netrin binds discrete subdomains of DCC and UNC5 and mediates interactions between DCC and heparin". The Journal of Biological Chemistry. 278 (35): 32561–8. doi:10.1074/jbc.M302943200. PMID 12810718.
• Llambi F, Lourenço FC, Gozuacik D, Guix C, Pays L, Del Rio G, et al. (March 2005). "The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase". The EMBO Journal. 24 (6): 1192–201. doi:10.1038/sj.emboj.7600584. PMC 556396. PMID 15729359.