ULK2

Unc-51-like kinase 2 (C. elegans) also known as ULK2 is an enzyme which in humans is encoded by the ULK2 gene.[1] The gene is located within the Smith–Magenis syndrome region on chromosome 17.

unc-51-like kinase 2 (C. elegans)
Identifiers
Symbol	ULK2
NCBI gene	9706
HGNC	13480
OMIM	608650
RefSeq	NM_014683
UniProt	Q8IYT8
Other data
EC number	2.7.11.1
Locus	Chr. 17 p11.2

Structure and function

This gene encodes a protein that is similar to a serine/threonine kinase in C. elegans which is involved in axonal elongation. The structure of this protein is similar to the C. elegans protein in that both proteins have an N-terminal kinase domain, a central proline/serine rich (PS) domain, and a C-terminal (C) domain.[2] ULK2 and the GTPase activating protein SynGAP function cooperatively in axon formation.[3]

References

1. Yan J, Kuroyanagi H, Tomemori T, Okazaki N, Asato K, Matsuda Y, Suzuki Y, Ohshima Y, Mitani S, Masuho Y, Shirasawa T, Muramatsu M (October 1999). "Mouse ULK2, a novel member of the UNC-51-like protein kinases: unique features of functional domains". Oncogene. 18 (43): 5850–9. doi:10.1038/sj.onc.1202988. PMID 10557072.
2. "Entrez Gene: ULK2".
3. Tomoda T, Kim JH, Zhan C, Hatten ME (March 2004). "Role of Unc51.1 and its binding partners in CNS axon outgrowth". Genes Dev. 18 (5): 541–58. doi:10.1101/gad.1151204. PMC 374236. PMID 15014045.

External links

• ULK2+protein,+mouse at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.