UFSP1

UFSP1
Identifiers
Aliases	UFSP1, UFSP, UFM1-specific peptidase 1 (inactive), UFM1 specific peptidase 1 (inactive)
External IDs	OMIM: 611481 MGI: 1917490 HomoloGene: 80245 GeneCards: UFSP1
Gene location (Human)
Chr.	Chromosome 7 (human)[1]
End	100,889,715 bp[1]
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)[2]
End	137,295,665 bp[2]
Gene ontology
Molecular function	• UFM1 hydrolase activity; • cysteine-type peptidase activity; • molecular function;
Cellular component	• extracellular exosome;
Biological process	• proteolysis; • biological process;
	Sources:Amigo / QuickGO
Orthologs
	402682
	70240
	ENSG00000176125
	ENSMUSG00000051502
	Q6NVU6
	Q9CZP0
	NM_001015072
	NM_027356
	NP_001015072
	NP_081632
	Wikidata
View/Edit Human	View/Edit Mouse

UFM1 specific peptidase 1 (inactive) is a protein that in humans is encoded by the UFSP1 gene.[5]

Function

This gene encodes a protein that is similar to other Ufm1-specific proteases. Studies in mouse determined that Ufsp1 releases Ufm1 (ubiquitin-fold modifier 1) from its bound conjugated complexes which also makes it into an active form. Because the human UFSP1 protein is shorter on the N-terminus and lacks a conserved Cys active site, it is predicted to be non-functional.[provided by RefSeq, Nov 2009].[5]

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References

GRCh38: Ensembl release 89: ENSG00000176125 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000051502 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: UFM1 specific peptidase 1 (inactive)". Retrieved 2020-04-15. This article incorporates text from this source, which is in the public domain.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000176125 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000051502 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: UFM1 specific peptidase 1 (inactive)". Retrieved 2020-04-15. This article incorporates text from this source, which is in the public domain.