UCbase

UCbase is a database of ultraconserved sequences (UCRs or UCEs) that were first described by Bejerano, G. et al.[2] in 2004. They are highly conserved genome regions that share 100% identity among human, mouse and rat. UCRs are 481 sequences longer than 200 bases. They are frequently located at genomic regions involved in cancer, differentially expressed in human leukemias and carcinomas and in some instances regulated by microRNAs.[3] The first release of UCbase was published by Taccioli, C. et al. in 2009.[4] Recent updates include new annotation based on hg19 Human genome, information about disorders related to the chromosome coordinates using the SNOMED CT classification, a query tool to search for SNPs, and a new text box to directly interrogate the database using a MySQL interface. Moreover, a sequence comparison tool allows the researchers to match selected sequences against ultraconserved elements located in genomic regions involved in specific disorders. To facilitate the interactive, visual interpretation of UCR chromosomal coordinates, the authors have implemented the graph visualization feature of UCbase creating a link to UCSC genome browser. UCbase 2.0 does not provide microRNAs (miRNAs) information anymore focusing only on UCRs. The official release of UCbase 2.0 was published in 2014[1] and is accessible at http://ucbase.unimore.it

UCbase 2.0
Content
Descriptionultraconserved sequences database.
OrganismsHomo sapiens
Mus musculus
Rattus norvegicus
Contact
Research centerThe Ohio State University
LaboratoryProfessor Carlo M. Croce, MD
AuthorsProfessor Cristian Taccioli, Ph.D
Primary citationTaccioli, C. et al. (2014)[1]
Release date2014
Access
Websitehttp://ucbase.unimore.it
Miscellaneous
Data release
frequency		6 months

See also
  • Sequence conservation

References
  1. Lomonaco, Vincenzo; Martoglia R; Mandreoli F; Anderlucci L; Emmett W; Bicciato S; Taccioli C. (Jan 2009). "UCbase 2.0: ultraconserved sequences database (2014 update)". Database. 2014: bau062. doi:10.1093/database/bau062. PMC 4064129. PMID 24951797.
  2. Bejerano, Gill; Pheasant M; Makunin I; Stephen S; Kent WJ; Mattick JS; Haussler D. (May 2004). "Ultraconserved elements in the human genome". Science. 304 (5675): 1321–5. Bibcode:2004Sci...304.1321B. CiteSeerX 10.1.1.380.9305. doi:10.1126/science.1098119. PMID 15131266.
  3. Calin GA, Liu CG, Ferracin M, Hyslop T, Spizzo R, Sevignani C, Fabbri M, Cimmino A, Lee EJ, Wojcik SE, Shimizu M, Tili E, Rossi S, Taccioli C, Pichiorri F, Liu X, Zupo S, Herlea V, Gramantieri L, Lanza G, Alder H, Rassenti L, Volinia S, Schmittgen TD, Kipps TJ, Negrini M, Croce CM (Sep 2007). "Ultraconserved regions encoding ncRNAs are altered in human leukemias and carcinomas". Cancer Cell. 12 (3): 215–29. doi:10.1016/j.ccr.2007.07.027. PMID 17785203.
  4. Taccioli C, Fabbri E, Visone R, Volinia S, Calin GA, Fong LY, Gambari R, Bottoni A, Acunzo M, Hagan J, Iorio MV, Piovan C, Romano G, Croce CM (Jan 2009). "UCbase & miRfunc: a database of ultraconserved sequences and microRNA function". Nucleic Acids Res. 37 (Database issue): D41–8. doi:10.1093/nar/gkn702. PMC 2686429. PMID 18945703.
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