Tymovirus coat protein

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Tymo_coat
	physalis mottle virus: empty capsid
Identifiers
Symbol	Tymo_coat
Pfam	PF00983
Pfam clan	CL0055
InterPro	IPR000574
SCOPe	1auy / SUPFAM
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

In molecular biology, the Tymovirus coat protein refers to the protein coat of a virus order, named Tymovirales. More specifically this protein signature is found only in coat proteins from the related tymoviruses. The coat protein (CP) is also known as the virion protein. The virus coat is composed of 180 copies of the coat protein arranged in an icosahedral shell.

Function

Fundamentally, the viral coat protein functions as protection for the genetic material inside the virus, and as an aid to infecting the host cell with virus DNA. Essentially, the coat protein (CP) is a link between the genetic material and infecting the host. Since the genetic material in the virus consists of RNA the coat protein contains RNA binding sites. Additionally, the coat protein contains conserved histadine amino acid residues which help the virus to spread.[1]

Structure

There are three subunits named, A, B and C. It contains a beta-jelly roll motif which consists of 9 beta-strands.[2]

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References

Bink HH, Pleij CW (2002). "RNA-protein interactions in spherical viruses". Arch Virol. 147 (12): 2261–79. doi:10.1007/s00705-002-0891-6. PMID 12491096.
Canady MA, Larson SB, Day J, McPherson A (1996). "Crystal structure of turnip yellow mosaic virus". Nat Struct Biol. 3 (9): 771–81. doi:10.1038/nsb0996-771. PMID 8784351.

This article incorporates text from the public domain Pfam and InterPro: IPR000574

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[pmid12491096-1] Bink HH, Pleij CW (2002). "RNA-protein interactions in spherical viruses". Arch Virol. 147 (12): 2261–79. doi:10.1007/s00705-002-0891-6. PMID 12491096.

[pmid8784351-2] Canady MA, Larson SB, Day J, McPherson A (1996). "Crystal structure of turnip yellow mosaic virus". Nat Struct Biol. 3 (9): 771–81. doi:10.1038/nsb0996-771. PMID 8784351.