Tweety family member 2

Tweety family member 2 is a protein that in humans is encoded by the TTYH2 gene.[5] Members of this family function as chloride channels. The encoded protein functions as a calcium(2+)-activated large conductance chloride(-) channel, and may play a role in kidney tumorigenesis. Two transcript variants encoding distinct isoforms have been identified for this gene.

TTYH2
Identifiers
Aliases	TTYH2, C17orf29, Tweety family member 2
External IDs	OMIM: 608855 MGI: 2157091 HomoloGene: 41882 GeneCards: TTYH2
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q25.1 Start 74,213,571 bp[1] End 74,262,020 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E2 Start 114,675,431 bp[2] End 114,720,977 bp[2]
Gene ontology Molecular function • GO:0001948 protein binding • chloride channel activity • intracellular calcium activated chloride channel activity • volume-sensitive chloride channel activity Cellular component • integral component of membrane • cell membrane • membrane • chloride channel complex Biological process • chloride transport • chloride transmembrane transport • ion transport • ion transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	94015	117160
Ensembl	ENSG00000141540	ENSMUSG00000034714
UniProt	Q9BSA4	Q3TH73
RefSeq (mRNA)	NM_032646 NM_052869 NM_001330453	NM_053273
RefSeq (protein)	NP_001317382 NP_116035 NP_443101	NP_444503
Location (UCSC)	Chr 17: 74.21 – 74.26 Mb	Chr 11: 114.68 – 114.72 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000141540 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000034714 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Tweety family member 2".

Further reading

• Bisson N, James DA, Ivosev G, Tate SA, Bonner R, Taylor L, Pawson T (June 2011). "Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor". Nature Biotechnology. 29 (7): 653–8. doi:10.1038/nbt.1905. PMID 21706016.
• Ibarrola N, Molina H, Iwahori A, Pandey A (April 2004). "A novel proteomic approach for specific identification of tyrosine kinase substrates using [13C]tyrosine". The Journal of Biological Chemistry. 279 (16): 15805–13. doi:10.1074/jbc.M311714200. PMID 14739304.
• Rae FK, Hooper JD, Eyre HJ, Sutherland GR, Nicol DL, Clements JA (October 2001). "TTYH2, a human homologue of the Drosophila melanogaster gene tweety, is located on 17q24 and upregulated in renal cell carcinoma". Genomics. 77 (3): 200–7. doi:10.1006/geno.2001.6629. PMID 11597145.
• Toiyama Y, Mizoguchi A, Kimura K, Hiro J, Inoue Y, Tutumi T, Miki C, Kusunoki M (May 2007). "TTYH2, a human homologue of the Drosophila melanogaster gene tweety, is up-regulated in colon carcinoma and involved in cell proliferation and cell aggregation". World Journal of Gastroenterology. 13 (19): 2717–21. doi:10.3748/wjg.v13.i19.2717. PMC 4147121. PMID 17569141.
• Suzuki M, Mizuno A (May 2004). "A novel human Cl(-) channel family related to Drosophila flightless locus". The Journal of Biological Chemistry. 279 (21): 22461–8. doi:10.1074/jbc.M313813200. PMID 15010458.
• He Y, Ramsay AJ, Hunt ML, Whitbread AK, Myers SA, Hooper JD (May 2008). "N-glycosylation analysis of the human Tweety family of putative chloride ion channels supports a penta-spanning membrane arrangement: impact of N-glycosylation on cellular processing of Tweety homologue 2 (TTYH2)". The Biochemical Journal. 412 (1): 45–55. doi:10.1042/BJ20071722. PMID 18260827.
• He Y, Hryciw DH, Carroll ML, Myers SA, Whitbread AK, Kumar S, Poronnik P, Hooper JD (August 2008). "The ubiquitin-protein ligase Nedd4-2 differentially interacts with and regulates members of the Tweety family of chloride ion channels". The Journal of Biological Chemistry. 283 (35): 24000–10. doi:10.1074/jbc.M803361200. PMC 3259790. PMID 18577513.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.