Tra (gene)
Female-specific protein transformer is a protein that in Drosophila melanogaster is encoded by the tra gene. Unlike the related tra2 protein, it is only produced in females.
Transformer | |||||||
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Identifiers | |||||||
Organism | |||||||
Symbol | tra | ||||||
Alt. symbols | CG16724; Dmel\CG16724; Dmtra | ||||||
Entrez | 39849 | ||||||
RefSeq (mRNA) | NM_079390.3 | ||||||
RefSeq (Prot) | NP_524114.1 | ||||||
UniProt | P11596 | ||||||
Other data | |||||||
Chromosome | 3L: 16.58 - 16.58 Mb | ||||||
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Fruit fly transformer | |||||||||
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Identifiers | |||||||||
Symbol | Transformer | ||||||||
Pfam | PF06495 | ||||||||
InterPro | IPR010519 | ||||||||
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Transformer-2 | |||||||
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Identifiers | |||||||
Organism | |||||||
Symbol | tra2 | ||||||
UniProt | P19018 | ||||||
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The transformer protein controls female somatic sexual differentiation.[2][3] The protein contains an RNA recognition motif. It controls the alternative splicing of the fly sex determination gene doublesex.[1]
References
- Verhulst EC, van de Zande L, Beukeboom LW (August 2010). "Insect sex determination: it all evolves around transformer" (PDF). Current Opinion in Genetics & Development. 20 (4): 376–83. doi:10.1016/j.gde.2010.05.001. PMID 20570131.
- Boggs RT, Gregor P, Idriss S, Belote JM, McKeown M (August 1987). "Regulation of sexual differentiation in D. melanogaster via alternative splicing of RNA from the transformer gene". Cell. 50 (5): 739–47. doi:10.1016/0092-8674(87)90332-1. PMID 2441872.
- Li H, Bingham PM (October 1991). "Arginine/serine-rich domains of the su(wa) and tra RNA processing regulators target proteins to a subnuclear compartment implicated in splicing". Cell. 67 (2): 335–42. doi:10.1016/0092-8674(91)90185-2. PMID 1655279.
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