Tg-PVR mouse

Tg-PVR mouse is a transgenic mouse, developed at the Central Institute for Experimental Animals (CIEA), carrying the human poliovirus receptor (PVR) gene, to be used in testing the neurovirulence of oral polio vaccine (OPV). The neurovirulent safety and consistency of OPV had been traditionally assayed in the monkey neurovirulence test (MNVT), as only primates, including humans and monkeys, are susceptible to polioviruses. After the development of the Tg-PVR mouse, the suitability of the mouse to replace monkeys for OPV testing was evaluated and confirmed.[1]

Origin

Characteristics
gollark: Yes, but it has to be as cool as countries.
gollark: All COOL countries have their own navigation satellites, so the EU has to be cool and have them too.
gollark: https://www.usegalileo.eu/EN/
gollark: Apparently some EU department decided that it was going to spend money on advertising the EU satellite navigation system to consumers. I don't know why they thought random people would care. It's kind of funny.
gollark: https://en.wikipedia.org/wiki/Crab_(unit) ← Rust (photometric)

References
  1. Bulletin of World Health Organization, 2003, 81 (4), pp.251-262
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.