TXNL4B

Thioredoxin-like protein 4B is a protein that in humans is encoded by the TXNL4B gene.[5][6]

TXNL4B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1XBS, 3GIX, 4IN0
Identifiers
Aliases	TXNL4B, DLP, Dim2, thioredoxin like 4B
External IDs	OMIM: 617722 MGI: 2443724 HomoloGene: 9880 GeneCards: TXNL4B
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q22.2 Start 72,044,289 bp[1] End 72,094,431 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 D3 Start 109,565,892 bp[2] End 109,574,051 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • U5 snRNP • cell nucleus • nucleoplasm • cytosol • spliceosomal complex • U4/U6 x U5 tri-snRNP complex Biological process • mRNA splicing, via spliceosome • cell cycle • mRNA processing • spliceosomal complex assembly • RNA splicing Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	54957	234723
Ensembl	ENSG00000140830	ENSMUSG00000031723
UniProt	Q9NX01	Q8BUH1
RefSeq (mRNA)	NM_017853 NM_001142317 NM_001142318 NM_001324354 NM_001324355	NM_175646
RefSeq (protein)	NP_001135789 NP_001135790 NP_001311283 NP_001311284 NP_060323	NP_783577
Location (UCSC)	Chr 16: 72.04 – 72.09 Mb	Chr 8: 109.57 – 109.57 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

TXNL4B has been shown to interact with PRPF6.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000140830 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031723 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sun X, Zhang H, Wang D, Ma D, Shen Y, Shang Y (Jul 2004). "DLP, a novel Dim1 family protein implicated in pre-mRNA splicing and cell cycle progression". J Biol Chem. 279 (31): 32839–47. doi:10.1074/jbc.M402522200. PMID 15161931.
6. "Entrez Gene: TXNL4B thioredoxin-like 4B".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Zhang YZ, Gould KL, Dunbrack RL JR, Cheng H, Roder H, Golemis EA (2001). "The evolutionarily conserved Dim1 protein defines a novel branch of the thioredoxin fold superfamily" (PDF). Physiol. Genomics. 1 (3): 109–18. PMID 11015569.
• Schelling P, Claus MT, Johner R, Marquez VE, Schulz GE, Scapozza L (2004). "Biochemical and structural characterization of (South)-methanocarbathymidine that specifically inhibits growth of herpes simplex virus type 1 thymidine kinase-transduced osteosarcoma cells". J. Biol. Chem. 279 (31): 32832–8. doi:10.1074/jbc.M313343200. PMID 15163659.
• Simeoni F, Arvai A, Bello P, Gondeau C, Hopfner KP, Neyroz P, Heitz F, Tainer J, Divita G (2005). "Biochemical characterization and crystal structure of a Dim1 family associated protein: Dim2". Biochemistry. 44 (36): 11997–2008. doi:10.1021/bi050427o. PMID 16142897.
• Jin T, Howard AJ, Golemis EA, Wang Y, Zhang YZ (2006). "Overproduction, purification, crystallization and preliminary X-ray diffraction studies of the human spliceosomal protein TXNL4B". Acta Crystallographica Section F. 61 (Pt 3): 282–4. doi:10.1107/S1744309105002861. PMC 1952293. PMID 16511018.