TWSG1

Twisted gastrulation protein homolog 1 is a protein that in humans is encoded by the TWSG1 gene.[5][6]

TWSG1
Identifiers
Aliases	TWSG1, TSG, twisted gastrulation BMP signaling modulator 1
External IDs	OMIM: 605049 MGI: 2137520 HomoloGene: 10774 GeneCards: TWSG1
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18p11.22 Start 9,334,767 bp[1] End 9,402,420 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 E1.1|17 35.26 cM Start 65,921,972 bp[2] End 65,951,226 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • transforming growth factor beta binding Cellular component • extracellular region • extracellular Biological process • negative regulation of BMP signaling pathway • multicellular organism development • mesoderm formation • cell differentiation • forebrain development • camera-type eye development • salivary gland morphogenesis • BMP signaling pathway • ossification • negative regulation of osteoblast differentiation • histogenesis • positive regulation of BMP signaling pathway • negative regulation of cytokine production • transforming growth factor beta receptor signaling pathway • positive regulation of pathway-restricted SMAD protein phosphorylation • negative regulation of CD4-positive, alpha-beta T cell activation • negative regulation of CD4-positive, alpha-beta T cell proliferation • haematopoiesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	57045	65960
Ensembl	ENSG00000128791	ENSMUSG00000024098
UniProt	Q9GZX9	Q9EP52
RefSeq (mRNA)	NM_020648	NM_023053
RefSeq (protein)	NP_065699	NP_075540
Location (UCSC)	Chr 18: 9.33 – 9.4 Mb	Chr 17: 65.92 – 65.95 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000128791 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024098 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Scott IC, Blitz IL, Pappano WN, Maas SA, Cho KW, Greenspan DS (Mar 2001). "Homologues of Twisted gastrulation are extracellular cofactors in antagonism of BMP signalling". Nature. 410 (6827): 475–8. doi:10.1038/35068572. PMID 11260715.
6. "Entrez Gene: TWSG1 twisted gastrulation homolog 1 (Drosophila)".

Further reading

• Oelgeschläger M, Larraín J, Geissert D, De Robertis EM (2000). "The evolutionarily conserved BMP-binding protein Twisted gastrulation promotes BMP signalling". Nature. 405 (6788): 757–63. doi:10.1038/35015500. PMC 2292104. PMID 10866189.
• Graf D, Timmons PM, Hitchins M, et al. (2001). "Evolutionary conservation, developmental expression, and genomic mapping of mammalian Twisted gastrulation". Mamm. Genome. 12 (7): 554–60. doi:10.1007/s0033501-0005-x. PMID 11420619.
• Graf D, Nethisinghe S, Palmer DB, et al. (2002). "The developmentally regulated expression of Twisted gastrulation reveals a role for bone morphogenetic proteins in the control of T cell development". J. Exp. Med. 196 (2): 163–71. doi:10.1084/jem.20020276. PMC 2193926. PMID 12119341.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Zakin L, De Robertis EM (2004). "Inactivation of mouse Twisted gastrulation reveals its role in promoting Bmp4 activity during forebrain development". Development. 131 (2): 413–24. doi:10.1242/dev.00946. PMID 14681194.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Moreno M, Muñoz R, Aroca F, et al. (2005). "Biglycan is a new extracellular component of the Chordin-BMP4 signaling pathway". EMBO J. 24 (7): 1397–405. doi:10.1038/sj.emboj.7600615. PMC 1142540. PMID 15775969.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Tzachanis D, Li L, Lafuente EM, et al. (2007). "Twisted gastrulation (Tsg) is regulated by Tob and enhances TGF-beta signaling in activated T lymphocytes". Blood. 109 (7): 2944–52. doi:10.1182/blood-2006-03-006510. PMC 1852213. PMID 17164348.