TUB (gene)

Tubby protein homolog is a protein that in humans is encoded by the TUB gene.[5][6]

TUB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1S31
Identifiers
Aliases	TUB, rd5, RDOB, tubby bipartite transcription factor, TUB bipartite transcription factor
External IDs	OMIM: 601197 MGI: 2651573 HomoloGene: 31147 GeneCards: TUB
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.4 Start 8,019,244 bp[1] End 8,106,112 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 E3|7 57.21 cM Start 108,950,338 bp[2] End 109,034,460 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • phosphatidylinositol binding • GO:0032403 macromolecular complex binding • G-protein coupled receptor binding • intraciliary transport particle A binding Cellular component • cytoplasm • extracellular region • cytosol • cell membrane • cilium • membrane • cell nucleus Biological process • phagocytosis, recognition • receptor localization to non-motile cilium • response to hormone • positive regulation of phagocytosis • photoreceptor cell maintenance • sensory perception of sound • retina development in camera-type eye • protein localization to photoreceptor outer segment • response to stimulus • phagocytosis • protein localization to cilium • regulation of G-protein coupled receptor protein signaling pathway • intraciliary transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7275	22141
Ensembl	ENSG00000166402	ENSMUSG00000031028
UniProt	P50607	P50586
RefSeq (mRNA)	NM_003320 NM_177972	NM_021885
RefSeq (protein)	NP_003311 NP_813977	NP_068685
Location (UCSC)	Chr 11: 8.02 – 8.11 Mb	Chr 7: 108.95 – 109.03 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the Tubby family of bipartite transcription factors. The encoded protein may play a role in obesity and sensorineural degradation. The crystal structure has been determined for a similar protein in mouse, and it functions as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis. Two transcript variants encoding distinct isoforms have been identified for this gene.[6]

Interactions

TUB (gene) has been shown to interact with PLCG1.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000166402 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031028 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kleyn PW, Fan W, Kovats SG, Lee JJ, Pulido JC, Wu Y, Berkemeier LR, Misumi DJ, Holmgren L, Charlat O, Woolf EA, Tayber O, Brody T, Shu P, Hawkins F, Kennedy B, Baldini L, Ebeling C, Alperin GD, Deeds J, Lakey ND, Culpepper J, Chen H, Glucksmann-Kuis MA, Carlson GA, Duyk GM, Moore KJ (Jun 1996). "Identification and characterization of the mouse obesity gene tubby: a member of a novel gene family". Cell. 85 (2): 281–90. doi:10.1016/S0092-8674(00)81104-6. PMID 8612280.
6. "Entrez Gene: TUB tubby homolog (mouse)".
7. Kapeller, R; Moriarty A; Strauss A; Stubdal H; Theriault K; Siebert E; Chickering T; Morgenstern J P; Tartaglia L A; Lillie J (Aug 1999). "Tyrosine phosphorylation of tub and its association with Src homology 2 domain-containing proteins implicate tub in intracellular signaling by insulin". J. Biol. Chem. UNITED STATES. 274 (35): 24980–6. doi:10.1074/jbc.274.35.24980. ISSN 0021-9258. PMID 10455176.

Further reading

• Ikeda A, Nishina PM, Naggert JK (2002). "The tubby-like proteins, a family with roles in neuronal development and function". J. Cell Sci. 115 (Pt 1): 9–14. PMID 11801719.
• Jones JM, Meisler MH, Seldin MF, et al. (1992). "Localization of insulin-2 (Ins-2) and the obesity mutant tubby (tub) to distinct regions of mouse chromosome 7". Genomics. 14 (1): 197–9. doi:10.1016/S0888-7543(05)80308-8. hdl:2027.42/29864. PMID 1358794.
• North MA, Naggert JK, Yan Y, et al. (1997). "Molecular characterization of TUB, TULP1, and TULP2, members of the novel tubby gene family and their possible relation to ocular diseases". Proc. Natl. Acad. Sci. U.S.A. 94 (7): 3128–33. Bibcode:1997PNAS...94.3128N. doi:10.1073/pnas.94.7.3128. PMC 20333. PMID 9096357.
• Kapeller R, Moriarty A, Strauss A, et al. (1999). "Tyrosine phosphorylation of tub and its association with Src homology 2 domain-containing proteins implicate tub in intracellular signaling by insulin". J. Biol. Chem. 274 (35): 24980–6. doi:10.1074/jbc.274.35.24980. PMID 10455176.
• Boggon TJ, Shan WS, Santagata S, et al. (1999). "Implication of tubby proteins as transcription factors by structure-based functional analysis". Science. 286 (5447): 2119–25. doi:10.1126/science.286.5447.2119. PMID 10591637.
• He W, Ikeda S, Bronson RT, et al. (2001). "GFP-tagged expression and immunohistochemical studies to determine the subcellular localization of the tubby gene family members". Brain Res. Mol. Brain Res. 81 (1–2): 109–17. doi:10.1016/S0169-328X(00)00164-9. PMID 11000483.
• Santagata S, Boggon TJ, Baird CL, et al. (2001). "G-protein signaling through tubby proteins". Science. 292 (5524): 2041–50. doi:10.1126/science.1061233. PMID 11375483.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Shiri-Sverdlov R, Custers A, van Vliet-Ostaptchouk JV, et al. (2006). "Identification of TUB as a novel candidate gene influencing body weight in humans". Diabetes. 55 (2): 385–9. doi:10.2337/diabetes.55.02.06.db05-0997. PMID 16443771.
• Giannaccini G, Giusti L, Santini F, et al. (2007). "Tubby protein in human lymphocytes from normal weight and obese subjects". Clin. Biochem. 40 (11): 806–9. doi:10.1016/j.clinbiochem.2007.03.020. PMID 17498679.

External links

• Overview of all the structural information available in the PDB for UniProt: P50607 (Human Tubby protein homolog) at the PDBe-KB.
• Overview of all the structural information available in the PDB for UniProt: P50586 (Mouse Tubby protein) at the PDBe-KB.