TUBGCP5

Gamma-tubulin complex component 5 is a protein that in humans is encoded by the TUBGCP5 gene.[5][6] It is part of the gamma tubulin complex, which required for microtubule nucleation at the centrosome.

TUBGCP5
Identifiers
Aliases	TUBGCP5, GCP5, tubulin gamma complex associated protein 5
External IDs	OMIM: 608147 MGI: 2178836 HomoloGene: 14172 GeneCards: TUBGCP5
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q11.2 Start 22,983,192 bp[1] End 23,039,572 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 B5 Start 55,794,154 bp[2] End 55,831,677 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • microtubule binding • structural constituent of cytoskeleton • microtubule minus-end binding • gamma-tubulin binding Cellular component • centrosome • spindle pole • equatorial microtubule organizing center • microtubule organizing center • spindle pole body • gamma-tubulin ring complex • microtubule • cytoskeleton • cytoplasm • cytosol • gamma-tubulin complex Biological process • centrosome duplication • interphase microtubule nucleation by interphase microtubule organizing center • mitotic spindle assembly • cytoplasmic microtubule organization • microtubule cytoskeleton organization • microtubule nucleation • GO:0007126 meiotic cell cycle • GO:0007067 mitotic cell cycle • spindle assembly Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	114791	233276
Ensembl	ENSG00000276856 ENSG00000275835 ENSG00000280807	ENSMUSG00000033790
UniProt	Q96RT8	Q8BKN5
RefSeq (mRNA)	NM_001102610 NM_052903 NM_001354372 NM_001354373 NM_001354374 NM_001354375 NM_001354376 NM_001354377 NM_001354378	NM_146190 NM_001360873 NM_001360874
RefSeq (protein)	NP_001096080 NP_443135 NP_001341301 NP_001341302 NP_001341303 NP_001341304 NP_001341305 NP_001341306 NP_001341307	NP_666302 NP_001347802 NP_001347803
Location (UCSC)	Chr 15: 22.98 – 23.04 Mb	Chr 7: 55.79 – 55.83 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Tubulin
• TUBGCP2
• TUBGCP3
• TUBGCP4
• TUBGCP6

References

1. ENSG00000275835, ENSG00000280807 GRCh38: Ensembl release 89: ENSG00000276856, ENSG00000275835, ENSG00000280807 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033790 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Murphy SM, Preble AM, Patel UK, O'Connell KL, Dias DP, Moritz M, Agard D, Stults JT, Stearns T (Nov 2001). "GCP5 and GCP6: two new members of the human gamma-tubulin complex" (PDF). Mol Biol Cell. 12 (11): 3340–52. doi:10.1091/mbc.12.11.3340. PMC 60259. PMID 11694571.
6. "Entrez Gene: TUBGCP5 tubulin, gamma complex associated protein 5".

Further reading

• Bittel DC, Kibiryeva N, Butler MG (2006). "Expression of 4 genes between chromosome 15 breakpoints 1 and 2 and behavioral outcomes in Prader–Willi syndrome". Pediatrics. 118 (4): e1276–83. doi:10.1542/peds.2006-0424. PMC 5453799. PMID 16982806.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Chai JH, Locke DP, Greally JM, et al. (2003). "Identification of four highly conserved genes between breakpoint hotspots BP1 and BP2 of the Prader-Willi/Angelman syndromes deletion region that have undergone evolutionary transposition mediated by flanking duplicons". Am. J. Hum. Genet. 73 (4): 898–925. doi:10.1086/378816. PMC 1180611. PMID 14508708.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Nagase T, Kikuno R, Ohara O (2002). "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins". DNA Res. 8 (4): 179–87. doi:10.1093/dnares/8.4.179. PMID 11572484.