TUBG1

Tubulin, gamma 1 is a protein in humans that is encoded by the TUBG1 gene.[5] This gene encodes a member of the tubulin superfamily. The encoded protein localizes to the centrosome where it binds to microtubules as part of a complex referred to as the gamma-tubulin ring complex. The protein mediates microtubule nucleation and is required for microtubule formation and progression of the cell cycle.

TUBG1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1Z5V, 1Z5W, 3CB2
Identifiers
Aliases	TUBG1, CDCBM4, GCP-1, TUBG, TUBGCP1, tubulin gamma 1
External IDs	OMIM: 191135 MGI: 101834 HomoloGene: 833 GeneCards: TUBG1
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.2 Start 42,609,683 bp[1] End 42,615,238 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 D|11 64.24 cM Start 101,119,938 bp[2] End 101,126,419 bp[2]
Gene ontology Molecular function • nucleotide binding • GTP binding • structural constituent of cytoskeleton • GO:0001948 protein binding • GTPase activity • identical protein binding Cellular component • cytoplasm • ciliary basal body • recycling endosome • cytosol • centrosome • pericentriolar material • apical part of cell • gamma-tubulin complex • cilium • microtubule organizing center • condensed nuclear chromosome • spindle microtubule • polar microtubule • cell leading edge • centriole • cytoplasmic microtubule • microtubule • cytoskeleton • non-motile cilium • cell nucleus • spindle Biological process • GO:0043147 meiotic spindle organization • G2/M transition of mitotic cell cycle • cytoplasmic microtubule organization • microtubule-based process • microtubule cytoskeleton organization • microtubule nucleation • ciliary basal body docking • regulation of G2/M transition of mitotic cell cycle • mitotic sister chromatid segregation • GO:0007067 mitotic cell cycle • GO:0043148 mitotic spindle organization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7283	103733
Ensembl	ENSG00000131462	ENSMUSG00000035198
UniProt	P23258	P83887
RefSeq (mRNA)	NM_001070	NM_134024
RefSeq (protein)	NP_001061	NP_598785
Location (UCSC)	Chr 17: 42.61 – 42.62 Mb	Chr 11: 101.12 – 101.13 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000131462 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035198 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Tubulin, gamma 1".

Further reading

• Zhang X, Chen Q, Feng J, Hou J, Yang F, Liu J, Jiang Q, Zhang C (July 2009). "Sequential phosphorylation of Nedd1 by Cdk1 and Plk1 is required for targeting of the gammaTuRC to the centrosome". Journal of Cell Science. 122 (Pt 13): 2240–51. doi:10.1242/jcs.042747. PMID 19509060.
• Lau AS, Mruk DD (April 2003). "Rab8B GTPase and junction dynamics in the testis". Endocrinology. 144 (4): 1549–63. doi:10.1210/en.2002-220893. PMID 12639940.
• Feng Y, Olson EC, Stukenberg PT, Flanagan LA, Kirschner MW, Walsh CA (December 2000). "LIS1 regulates CNS lamination by interacting with mNudE, a central component of the centrosome". Neuron. 28 (3): 665–79. doi:10.1016/S0896-6273(00)00145-8. PMID 11163258.
• Hsu LC, White RL (October 1998). "BRCA1 is associated with the centrosome during mitosis". Proceedings of the National Academy of Sciences of the United States of America. 95 (22): 12983–8. doi:10.1073/pnas.95.22.12983. PMC 23679. PMID 9789027.
• Manning JA, Shalini S, Risk JM, Day CL, Kumar S (March 2010). Hotchin NA (ed.). "A direct interaction with NEDD1 regulates gamma-tubulin recruitment to the centrosome". PLoS One. 5 (3): e9618. doi:10.1371/journal.pone.0009618. PMC 2835750. PMID 20224777.
• Aldaz H, Rice LM, Stearns T, Agard DA (May 2005). "Insights into microtubule nucleation from the crystal structure of human gamma-tubulin". Nature. 435 (7041): 523–7. doi:10.1038/nature03586. PMID 15917813.
• Niu Y, Liu T, Tse GM, Sun B, Niu R, Li HM, Wang H, Yang Y, Ye X, Wang Y, Yu Q, Zhang F (April 2009). "Increased expression of centrosomal alpha, gamma-tubulin in atypical ductal hyperplasia and carcinoma of the breast". Cancer Science. 100 (4): 580–7. doi:10.1111/j.1349-7006.2008.01075.x. PMID 19215229.
• Hampe C, Ardila-Osorio H, Fournier M, Brice A, Corti O (July 2006). "Biochemical analysis of Parkinson's disease-causing variants of Parkin, an E3 ubiquitin-protein ligase with monoubiquitylation capacity". Human Molecular Genetics. 15 (13): 2059–75. doi:10.1093/hmg/ddl131. PMID 16714300.
• Zyss D, Montcourrier P, Vidal B, Anguille C, Mérezègue F, Sahuquet A, Mangeat PH, Coopman PJ (December 2005). "The Syk tyrosine kinase localizes to the centrosomes and negatively affects mitotic progression". Cancer Research. 65 (23): 10872–80. doi:10.1158/0008-5472.CAN-05-1270. PMID 16322234.