TTI2

TELO2 interacting protein 2 is a protein that in humans is encoded by the TTI2 gene. [5]

TTI2
Identifiers
AliasesTTI2, C8orf41, MRT39, TELO2 interacting protein 2
External IDsOMIM: 614426 MGI: 2384576 HomoloGene: 11836 GeneCards: TTI2
Gene location (Human)
Chr.Chromosome 8 (human)[1]
Band8p12Start33,473,386 bp[1]
End33,513,601 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

80185

234138

Ensembl

ENSG00000129696

ENSMUSG00000031577

UniProt

Q6NXR4

Q8BGV4

RefSeq (mRNA)

NM_001102401
NM_001265581
NM_025115
NM_001330505

NM_001112729
NM_001199988
NM_144927

RefSeq (protein)

NP_001095871
NP_001252510
NP_001317434
NP_079391

NP_001186917
NP_659176

Location (UCSC)Chr 8: 33.47 – 33.51 MbChr 8: 31.15 – 31.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a regulator of the DNA damage response. The protein is a component of the Triple T complex (TTT) which also includes telomere length regulation protein and TELO2 interacting protein 1.

The TTT complex is involved in cellular resistance to DNA damage stresses and may act as a regulator of phosphoinositide-3-kinase-related protein kinase (PIKK) abundance.

gollark: Thus UBI or something, yes.
gollark: As I said, I'd prefer being given choices about that than having someone say I can't have X food.
gollark: That seems somewhat arbitrary.
gollark: No, I mean by the government, which probably has to go to lots of effort to run such a system and define what "food" is.
gollark: So would just giving people money to spend on food. Less overhead with working out what counts as acceptable food too probably.

References
  1. GRCh38: Ensembl release 89: ENSG00000129696 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000031577 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: TELO2 interacting protein 2". Retrieved 2016-12-14.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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