TSPYL2

Testis-specific Y-encoded-like protein 2 is a protein that in humans is encoded by the TSPYL2 gene.[5][6][7]

TSPYL2
Identifiers
Aliases	TSPYL2, CDA1, CINAP, CTCL, DENTT, HRIHFB2216, NP79, SE204, TSPX, TSPY-like 2, TSPY like 2
External IDs	OMIM: 300564 MGI: 106244 HomoloGene: 11140 GeneCards: TSPYL2
Gene location (Human) Chr. X chromosome (human)[1] Band Xp11.22 Start 53,082,367 bp[1] End 53,088,540 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X F3|X 68.46 cM Start 152,336,852 bp[2] End 152,342,425 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • rDNA binding • GO:0001948 protein binding Cellular component • nucleolus • nucleoplasm • cell nucleus • cytoplasm Biological process • cell cycle • nucleosome assembly • IRE1-mediated unfolded protein response • negative regulation of cell cycle • negative regulation of DNA replication • regulation of protein kinase activity • regulation of transcription, DNA-templated • regulation of signal transduction • negative regulation of cell growth • transcription, DNA-templated • chromatin organization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	64061	52808
Ensembl	ENSG00000184205	ENSMUSG00000041096
UniProt	Q9H2G4	Q7TQI8
RefSeq (mRNA)	NM_022117	NM_029836 NM_145936 NM_001358369
RefSeq (protein)	NP_071400	NP_084112 NP_001345298
Location (UCSC)	Chr X: 53.08 – 53.09 Mb	Chr X: 152.34 – 152.34 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000184205 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000041096 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ozbun LL, You L, Kiang S, Angdisen J, Martinez A, Jakowlew SB (Apr 2001). "Identification of differentially expressed nucleolar TGF-beta1 target (DENTT) in human lung cancer cells that is a new member of the TSPY/SET/NAP-1 superfamily" (Submitted manuscript). Genomics. 73 (2): 179–93. doi:10.1006/geno.2001.6505. PMID 11318608.
6. Chai Z, Sarcevic B, Mawson A, Toh BH (Sep 2001). "SET-related cell division autoantigen-1 (CDA1) arrests cell growth". J Biol Chem. 276 (36): 33665–74. doi:10.1074/jbc.M007681200. PMID 11395479.
7. "Entrez Gene: TSPYL2 TSPY-like 2".

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Eichmuller S, Usener D, Dummer R, et al. (2001). "Serological detection of cutaneous T-cell lymphoma-associated antigens". Proc. Natl. Acad. Sci. U.S.A. 98 (2): 629–34. doi:10.1073/pnas.021386498. PMC 14639. PMID 11149944.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Wang GS, Hong CJ, Yen TY, et al. (2004). "Transcriptional modification by a CASK-interacting nucleosome assembly protein". Neuron. 42 (1): 113–28. doi:10.1016/S0896-6273(04)00139-4. PMID 15066269.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Santama N, Ogg SC, Malekkou A, et al. (2006). "Characterization of hCINAP, a novel coilin-interacting protein encoded by a transcript from the transcription factor TAFIID32 locus". J. Biol. Chem. 280 (43): 36429–41. doi:10.1074/jbc.M501982200. PMID 16079131.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
• Radke JR, Donald RG, Eibs A, et al. (2006). "Changes in the expression of human cell division autoantigen-1 influence Toxoplasma gondii growth and development". PLoS Pathog. 2 (10): e105. doi:10.1371/journal.ppat.0020105. PMC 1626100. PMID 17069459.
• Tu Y, Wu W, Wu T, et al. (2007). "Antiproliferative autoantigen CDA1 transcriptionally up-regulates p21(Waf1/Cip1) by activating p53 and MEK/ERK1/2 MAPK pathways". J. Biol. Chem. 282 (16): 11722–31. doi:10.1074/jbc.M609623200. PMID 17317670.