TRIP11

Thyroid receptor-interacting protein 11 is a protein that in humans is encoded by the TRIP11 gene.[5][6][7]

TRIP11
Identifiers
Aliases	TRIP11, ACG1A, CEV14, GMAP-210, TRIP-11, TRIP230, GMAP210, thyroid hormone receptor interactor 11, ODCD
External IDs	OMIM: 604505 MGI: 1924393 HomoloGene: 20897 GeneCards: TRIP11
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q32.12 Start 91,965,991 bp[1] End 92,040,896 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 E Start 101,834,043 bp[2] End 101,913,267 bp[2]
Gene ontology Molecular function • GO:0001105 transcription coactivator activity • GO:0001948 protein binding Cellular component • cytoplasm • inner acrosomal membrane • Golgi membrane • cis-Golgi network • Golgi apparatus • outer acrosomal membrane • cytoskeleton • membrane • acrosomal membrane • cell nucleus • transport vesicle • cilium • nuclear speck Biological process • transcription from RNA polymerase II promoter • ventricular septum development • bone development • inner ear receptor stereocilium organization • Golgi organization • chondrocyte differentiation involved in endochondral bone morphogenesis • protein glycosylation • intraciliary transport involved in cilium assembly • positive regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9321	109181
Ensembl	ENSG00000100815	ENSMUSG00000021188
UniProt	Q15643	n/a
RefSeq (mRNA)	NM_004239 NM_001321851	NM_028446
RefSeq (protein)	NP_001308780 NP_004230	n/a
Location (UCSC)	Chr 14: 91.97 – 92.04 Mb	Chr 12: 101.83 – 101.91 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

TRIP11 was first identified through its ability to interact functionally with thyroid hormone receptor-beta (THRB; MIM 190160). It has also been found in association with the Golgi apparatus and microtubules.[supplied by OMIM][7]

Interactions

TRIP11 has been shown to interact with Retinoblastoma protein[8] and Thyroid hormone receptor alpha.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000100815 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021188 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lee JW, Choi HS, Gyuris J, Brent R, Moore DD (Feb 1995). "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor". Molecular Endocrinology. 9 (2): 243–54. doi:10.1210/me.9.2.243. PMID 7776974.
6. Abe A, Emi N, Tanimoto M, Terasaki H, Marunouchi T, Saito H (Dec 1997). "Fusion of the platelet-derived growth factor receptor beta to a novel gene CEV14 in acute myelogenous leukemia after clonal evolution". Blood. 90 (11): 4271–7. PMID 9373237.
7. "Entrez Gene: TRIP11 thyroid hormone receptor interactor 11".
8. Chang KH, Chen Y, Chen TT, Chou WH, Chen PL, Ma YY, Yang-Feng TL, Leng X, Tsai MJ, O'Malley BW, Lee WH (Aug 1997). "A thyroid hormone receptor coactivator negatively regulated by the retinoblastoma protein". Proceedings of the National Academy of Sciences of the United States of America. 94 (17): 9040–5. doi:10.1073/pnas.94.17.9040. PMC 23019. PMID 9256431.

Further reading

• Chang KH, Chen Y, Chen TT, Chou WH, Chen PL, Ma YY, Yang-Feng TL, Leng X, Tsai MJ, O'Malley BW, Lee WH (Aug 1997). "A thyroid hormone receptor coactivator negatively regulated by the retinoblastoma protein". Proceedings of the National Academy of Sciences of the United States of America. 94 (17): 9040–5. doi:10.1073/pnas.94.17.9040. PMC 23019. PMID 9256431.
• Infante C, Ramos-Morales F, Fedriani C, Bornens M, Rios RM (Apr 1999). "GMAP-210, A cis-Golgi network-associated protein, is a minus end microtubule-binding protein". The Journal of Cell Biology. 145 (1): 83–98. doi:10.1083/jcb.145.1.83. PMC 2148210. PMID 10189370.
• Ramos-Morales F, Vime C, Bornens M, Fedriani C, Rios RM (Aug 2001). "Two splice variants of Golgi-microtubule-associated protein of 210 kDa (GMAP-210) differ in their binding to the cis-Golgi network". The Biochemical Journal. 357 (Pt 3): 699–708. doi:10.1042/0264-6021:3570699. PMC 1221999. PMID 11463340.
• Pernet-Gallay K, Antony C, Johannes L, Bornens M, Goud B, Rios RM (Nov 2002). "The overexpression of GMAP-210 blocks anterograde and retrograde transport between the ER and the Golgi apparatus". Traffic. 3 (11): 822–32. doi:10.1034/j.1600-0854.2002.31107.x. PMID 12383348.
• Beischlag TV, Taylor RT, Rose DW, Yoon D, Chen Y, Lee WH, Rosenfeld MG, Hankinson O (Dec 2004). "Recruitment of thyroid hormone receptor/retinoblastoma-interacting protein 230 by the aryl hydrocarbon receptor nuclear translocator is required for the transcriptional response to both dioxin and hypoxia". The Journal of Biological Chemistry. 279 (52): 54620–8. doi:10.1074/jbc.M410456200. PMID 15485806.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Kob R, Baniahmad A, Escher N, von Eggeling F, Melle C (Apr 2007). "Detection and identification of transcription factors as interaction partners of alien in vivo". Cell Cycle. 6 (8): 993–6. doi:10.4161/cc.6.8.4108. PMID 17438371.