TRIM69

Tripartite motif containing 69 is a protein that in humans is encoded by the TRIM69 gene. [5]

TRIM69
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTRIM69, HSD-34, HSD34, RNF36, Trif, tripartite motif containing 69
External IDsOMIM: 616017 MGI: 1918178 HomoloGene: 18827 GeneCards: TRIM69
Gene location (Human)
Chr.Chromosome 15 (human)[1]
Band15q21.1Start44,728,988 bp[1]
End44,767,829 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

140691

70928

Ensembl

ENSG00000278211
ENSG00000185880

ENSMUSG00000033368

UniProt

Q86WT6

Q80X56

RefSeq (mRNA)

NM_182985
NM_001301144
NM_001301145
NM_001301146
NM_080745

NM_080510
NM_001379369

RefSeq (protein)

NP_001288073
NP_001288074
NP_001288075
NP_542783
NP_892030

NP_536771
NP_001366298

Location (UCSC)Chr 15: 44.73 – 44.77 MbChr 2: 122.16 – 122.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a member of the RING-B-box-coiled-coil (RBCC) family and encodes a protein with an N-terminal RING finger motif, a PRY domain and a C-terminal SPRY domain. The mouse ortholog of this gene is specifically expressed in germ cells at the round spermatid stages during spermatogenesis and, when overexpressed, induces apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described.

gollark: If you *do* go around using a definition which admits stars and everything else, it's basically meaningless, but ends up bringing all the weird things English ties to "life" and "organisms" along with it anywya.
gollark: Which are mostly for some specific technical context and make sense there. Because it's a hard to define word.
gollark: The broader issue is that when people say stuff like that they generally mean to sneak in a bunch of connotations which are dragged along with "organism" or "life".
gollark: You could *maybe* stretch that to extend to *all* humans, but *also* probably-not-organism things like stars, which also reproduce (ish), process things into usable energy (ish), sort of respond to stimuli for very broad definitions of stimuli, maintain a balance between radiation pressure and gravity, and grow (ish).
gollark: Individual humans are "organisms" by any sensible definition, inasmuch as they... reproduce, think, maintain homeostasis, grow, respond to stimuli, process inputs into usable energy and whatever.

References
  1. ENSG00000185880 GRCh38: Ensembl release 89: ENSG00000278211, ENSG00000185880 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000033368 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Tripartite motif containing 69". Retrieved 2016-02-16.
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human E3 ubiquitin-protein ligase TRIM69

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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