TRIM38

TRIM38
Identifiers
Aliases	TRIM38, RNF15, RORET, tripartite motif containing 38
External IDs	MGI: 2684869 HomoloGene: 48427 GeneCards: TRIM38
Gene location (Human)
Chr.	Chromosome 6 (human)[1]
End	25,991,231 bp[1]
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)[2]
End	23,791,528 bp[2]
Gene ontology
Molecular function	• zinc ion binding; • signal transducer activity; • metal ion binding; • GO:0001948 protein binding; • transferase activity;
Cellular component	• cytosol; • intracellular;
Biological process	• immune system process; • interferon-gamma-mediated signaling pathway; • positive regulation of sequence-specific DNA binding transcription factor activity; • positive regulation of NF-kappaB transcription factor activity; • protein ubiquitination; • positive regulation of I-kappaB kinase/NF-kappaB signaling; • innate immune system;
	Sources:Amigo / QuickGO
Orthologs
	10475
	214158
	ENSG00000112343
	ENSMUSG00000064140
	O00635
	Q5SZ99
	NM_006355
	NM_001029935
	NP_006346
	NP_001025106
	Wikidata
View/Edit Human	View/Edit Mouse

Tripartite motif containing 38 is a protein that in humans is encoded by the TRIM38 gene. [5]

Function

This gene encodes a member of the tripartite motif (TRIM) family. The encoded protein contains a RING-type zinc finger, B box-type zinc finger and SPRY domain. The function of this protein has not been identified. A pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Jul 2012].

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References

GRCh38: Ensembl release 89: ENSG00000112343 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000064140 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: Tripartite motif containing 38". Retrieved 2018-03-21.

Liu X, Lei X, Zhou Z, Sun Z, Xue Q, Wang J, Hung T (February 2011). "Enterovirus 71 induces degradation of TRIM38, a potential E3 ubiquitin ligase". Virol. J. 8: 61. doi:10.1186/1743-422X-8-61. PMC 3048563. PMID 21306652.
Liu XL, Lei XB, Wang JW, Hong T (February 2011). "[Identification A novel protein TRIM38 that activate NF-kappaB signaling pathways]". Zhonghua Shi Yan He Lin Chuang Bing du Xue Za Zhi (in Chinese). 25 (1): 60–2. PMID 21789858.
Xue Q, Zhou Z, Lei X, Liu X, He B, Wang J, Hung T (2012). "TRIM38 negatively regulates TLR3-mediated IFN-β signaling by targeting TRIF for degradation". PLOS ONE. 7 (10): e46825. doi:10.1371/journal.pone.0046825. PMC 3466175. PMID 23056470.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000112343 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000064140 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Tripartite motif containing 38". Retrieved 2018-03-21.

TRIM38

Function

References

Further reading