TRIM3
Tripartite motif-containing protein 3 is a protein that in humans is encoded by the TRIM3 gene.[5][6]
The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also called the 'RING-B-box-coiled-coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic filaments. It is similar to a rat protein which is a specific partner for the tail domain of myosin V, a class of myosins which are involved in the targeted transport of organelles. The rat protein can also interact with alpha-actinin-4. Thus it is suggested that this human protein may play a role in myosin V-mediated cargo transport. Alternatively spliced transcript variants encoding the same isoform have been identified.[6]
Interactions
TRIM3 has been shown to interact with Actinin alpha 4.[7]
gollark: My slightly newer SomethingOrOther 5000 does too.
gollark: ```Architecture: x86_64CPU op-mode(s): 32-bit, 64-bitByte Order: Little EndianCPU(s): 4On-line CPU(s) list: 0-3Thread(s) per core: 1Core(s) per socket: 4Socket(s): 1NUMA node(s): 1Vendor ID: AuthenticAMDCPU family: 23Model: 1Model name: AMD Ryzen 3 1200 Quad-Core ProcessorStepping: 1CPU MHz: 3338.023CPU max MHz: 3500.0000CPU min MHz: 1550.0000BogoMIPS: 6989.03Virtualization: AMD-VL1d cache: 32KL1i cache: 64KL2 cache: 512KL3 cache: 4096KNUMA node0 CPU(s): 0-3Flags: fpu vme de pse tsc msr pae mce cx8 apic sep mtrr pge mca cmov pat pse36 clflush mmx fxsr sse sse2 ht syscall nx mmxext fxsr_opt pdpe1gb rdtscp lm constant_tsc rep_good nopl nonstop_tsc cpuid extd_apicid aperfmperf pni pclmulqdq monitor ssse3 fma cx16 sse4_1 sse4_2 movbe popcnt aes xsave avx f16c rdrand lahf_lm cmp_legacy svm extapic cr8_legacy abm sse4a misalignsse 3dnowprefetch osvw skinit wdt tce topoext perfctr_core perfctr_nb bpext perfctr_llc mwaitx cpb hw_pstate sme ssbd sev vmmcall fsgsbase bmi1 avx2 smep bmi2 rdseed adx smap clflushopt sha_ni xsaveopt xsavec xgetbv1 xsaves clzero irperf xsaveerptr arat npt lbrv svm_lock nrip_save tsc_scale vmcb_clean flushbyasid decodeassists pausefilter pfthreshold avic v_vmsave_vmload vgif overflow_recov succor smca```What clear, useful output.
gollark: `lscpu` on Li'nux.
gollark: How do you know?
gollark: https://www.dell.com/downloads/global/products/pedge/en/2950_specs.pdf
References
- GRCh38: Ensembl release 89: ENSG00000110171 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000036989 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- El-Husseini AE, Vincent SR (July 1999). "Cloning and characterization of a novel RING finger protein that interacts with class V myosins". The Journal of Biological Chemistry. 274 (28): 19771–7. doi:10.1074/jbc.274.28.19771. PMID 10391919.
- "Entrez Gene: TRIM3 tripartite motif-containing 3".
- El-Husseini AE, Kwasnicka D, Yamada T, Hirohashi S, Vincent SR (January 2000). "BERP, a novel ring finger protein, binds to alpha-actinin-4". Biochemical and Biophysical Research Communications. 267 (3): 906–11. doi:10.1006/bbrc.1999.2045. PMID 10673389.
Further reading
- El-Husseini AE, Kwasnicka D, Yamada T, Hirohashi S, Vincent SR (January 2000). "BERP, a novel ring finger protein, binds to alpha-actinin-4". Biochemical and Biophysical Research Communications. 267 (3): 906–11. doi:10.1006/bbrc.1999.2045. PMID 10673389.
- El-Husseini AE, Fretier P, Vincent SR (February 2001). "Cloning and characterization of a gene (RNF22) encoding a novel brain expressed ring finger protein (BERP) that maps to human chromosome 11p15.5". Genomics. 71 (3): 363–7. doi:10.1006/geno.2000.6452. PMID 11170753.
- Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". The EMBO Journal. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245. PMID 11331580.
- Lee SJ, Choi JY, Sung YM, Park H, Rhim H, Kang S (August 2001). "E3 ligase activity of RING finger proteins that interact with Hip-2, a human ubiquitin-conjugating enzyme". FEBS Letters. 503 (1): 61–4. doi:10.1016/S0014-5793(01)02689-8. PMID 11513855.
- Yan Q, Sun W, Kujala P, Lotfi Y, Vida TA, Bean AJ (May 2005). "CART: an Hrs/actinin-4/BERP/myosin V protein complex required for efficient receptor recycling". Molecular Biology of the Cell. 16 (5): 2470–82. doi:10.1091/mbc.E04-11-1014. PMC 1087250. PMID 15772161.
- Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
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