TRERF1

Transcriptional-regulating factor 1 is a protein that in humans is encoded by the TRERF1 gene.[4][5]

TRERF1
Identifiers
Aliases	TRERF1, BCAR2, HSA277276, RAPA, TREP132, TReP-132, dJ139D8.5, transcriptional regulating factor 1
External IDs	OMIM: 610322 MGI: 2442086 HomoloGene: 14129 GeneCards: TRERF1
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.1 Start 42,224,931 bp[1] End 42,452,051 bp[1]
Gene ontology Molecular function • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • metal ion binding • GO:0001104 transcription cofactor activity • DNA binding • DNA binding, bending • ligand-dependent nuclear receptor transcription coactivator activity • transcription factor binding • nucleic acid binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • cell nucleus • histone deacetylase complex • transcription factor complex • nucleoplasm • nucleolus • cytosol Biological process • multicellular organism development • cholesterol catabolic process • regulation of transcription, DNA-templated • homeostatic process • steroid biosynthetic process • positive regulation of transcription, DNA-templated • transcription, DNA-templated • regulation of hormone biosynthetic process • regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55809	224829
Ensembl	ENSG00000124496	n/a
UniProt	Q96PN7	Q8BXJ2
RefSeq (mRNA)	NM_001297573 NM_018415 NM_033501 NM_033502	NM_001097623 NM_172622
RefSeq (protein)	NP_001284502 NP_277037	NP_001091092 NP_766210
Location (UCSC)	Chr 6: 42.22 – 42.45 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a zinc-finger transcriptional regulating protein that interacts with CBP/p300 to regulate the human gene CYP11A1.[5]

Interactions

TRERF1 has been shown to interact with Steroidogenic factor 1,[6] EP300[4] and CREB-binding protein.[4]

References

1. GRCh38: Ensembl release 89: ENSG00000124496 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Gizard F, Lavallée B, DeWitte F, Hum DW (September 2001). "A novel zinc finger protein TReP-132 interacts with CBP/p300 to regulate human CYP11A1 gene expression". The Journal of Biological Chemistry. 276 (36): 33881–92. doi:10.1074/jbc.M100113200. PMID 11349124.
5. "Entrez Gene: TRERF1 transcriptional regulating factor 1".
6. Gizard F, Lavallee B, DeWitte F, Teissier E, Staels B, Hum DW (October 2002). "The transcriptional regulating protein of 132 kDa (TReP-132) enhances P450scc gene transcription through interaction with steroidogenic factor-1 in human adrenal cells". The Journal of Biological Chemistry. 277 (42): 39144–55. doi:10.1074/jbc.M205786200. PMID 12101186.

Further reading

• Dorssers LC, Veldscholte J (August 1997). "Identification of a novel breast-cancer-anti-estrogen-resistance (BCAR2) locus by cell-fusion-mediated gene transfer in human breast-cancer cells". International Journal of Cancer. 72 (4): 700–5. doi:10.1002/(SICI)1097-0215(19970807)72:4<700::AID-IJC24>3.0.CO;2-D. PMID 9259413.
• Gizard F, Lavallee B, DeWitte F, Teissier E, Staels B, Hum DW (October 2002). "The transcriptional regulating protein of 132 kDa (TReP-132) enhances P450scc gene transcription through interaction with steroidogenic factor-1 in human adrenal cells". The Journal of Biological Chemistry. 277 (42): 39144–55. doi:10.1074/jbc.M205786200. PMID 12101186.
• Gizard F, El-Alfy M, Duguay Y, Lavallée B, DeWitte F, Staels B, et al. (November 2002). "Function of the transcriptional regulating protein of 132 kDa (TReP-132) on human P450scc gene expression". Endocrine Research. 28 (4): 559–74. doi:10.1081/ERC-120016841. PMID 12530663.
• Gizard F, Teissier E, Dufort I, Luc G, Luu-The V, Staels B, Hum DW (April 2004). "The transcriptional regulating protein of 132 kDa (TReP-132) differentially influences steroidogenic pathways in human adrenal NCI-H295 cells". Journal of Molecular Endocrinology. 32 (2): 557–69. doi:10.1677/jme.0.0320557. PMID 15072559.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, et al. (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gizard F, Robillard R, Barbier O, Quatannens B, Faucompré A, Révillion F, et al. (June 2005). "TReP-132 controls cell proliferation by regulating the expression of the cyclin-dependent kinase inhibitors p21WAF1/Cip1 and p27Kip1". Molecular and Cellular Biology. 25 (11): 4335–48. doi:10.1128/MCB.25.11.4335-4348.2005. PMC 1140623. PMID 15899840.
• Gizard F, Robillard R, Gross B, Barbier O, Révillion F, Peyrat JP, et al. (October 2006). "TReP-132 is a novel progesterone receptor coactivator required for the inhibition of breast cancer cell growth and enhancement of differentiation by progesterone". Molecular and Cellular Biology. 26 (20): 7632–44. doi:10.1128/MCB.00326-06. PMC 1636875. PMID 17015480.