TRAK2

Trafficking kinesin-binding protein 2 is a protein that in humans is encoded by the TRAK2 gene.[5][6][7]

TRAK2
Identifiers
Aliases	TRAK2, ALS2CR3, CALS-C, GRIF-1, GRIF1, MILT2, OIP98, trafficking kinesin protein 2
External IDs	OMIM: 607334 MGI: 1918077 HomoloGene: 22861 GeneCards: TRAK2
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q33.1 Start 201,377,207 bp[1] End 201,451,500 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 C1.3 Start 58,900,449 bp[2] End 58,973,430 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • receptor binding • GO:0001948 protein binding • GABA receptor binding • kinesin binding • TPR domain binding • enzyme binding • myosin binding Cellular component • cytoplasm • endosome • cell membrane • early endosome • mitochondrion • cell nucleus • dendrite cytoplasm • dendrite • neuron projection • neuronal cell body • axonal growth cone • cytoplasmic vesicle • axon cytoplasm Biological process • regulation of transcription from RNA polymerase II promoter • protein targeting • protein O-linked glycosylation • anterograde dendritic transport of mitochondrion • endosome to lysosome transport • dendrite morphogenesis • negative regulation of axonogenesis • dendritic transport of mitochondrion • anterograde axonal transport • protein localization • neurogenesis • vesicle transport along microtubule • mitochondrion distribution • anterograde axonal transport of mitochondrion Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	66008	70827
Ensembl	ENSG00000115993	ENSMUSG00000026028
UniProt	O60296	n/a
RefSeq (mRNA)	NM_015049	NM_172406
RefSeq (protein)	NP_055864	n/a
Location (UCSC)	Chr 2: 201.38 – 201.45 Mb	Chr 1: 58.9 – 58.97 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

TRAK2 has been shown to interact with Kir2.1[8] and GABRB2.[9]

References

1. GRCh38: Ensembl release 89: ENSG00000115993 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026028 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hadano S, Yanagisawa Y, Skaug J, Fichter K, Nasir J, Martindale D, Koop BF, Scherer SW, Nicholson DW, Rouleau GA, Ikeda J, Hayden MR (Jan 2001). "Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: candidate genes for ALS2". Genomics. 71 (2): 200–13. doi:10.1006/geno.2000.6392. PMID 11161814.
6. Gilbert SL, Zhang L, Forster ML, Anderson JR, Iwase T, Soliven B, Donahue LR, Sweet HO, Bronson RT, Davisson MT, Wollmann RL, Lahn BT (Feb 2006). "Trak1 mutation disrupts GABA(A) receptor homeostasis in hypertonic mice". Nature Genetics. 38 (2): 245–50. doi:10.1038/ng1715. PMID 16380713.
7. "Entrez Gene: TRAK2 trafficking protein, kinesin binding 2".
8. Grishin A, Li H, Levitan ES, Zaks-Makhina E (Oct 2006). "Identification of gamma-aminobutyric acid receptor-interacting factor 1 (TRAK2) as a trafficking factor for the K+ channel Kir2.1". The Journal of Biological Chemistry. 281 (40): 30104–11. doi:10.1074/jbc.M602439200. PMID 16895905.
9. Beck M, Brickley K, Wilkinson HL, Sharma S, Smith M, Chazot PL, Pollard S, Stephenson FA (Aug 2002). "Identification, molecular cloning, and characterization of a novel GABAA receptor-associated protein, GRIF-1". The Journal of Biological Chemistry. 277 (33): 30079–90. doi:10.1074/jbc.M200438200. PMID 12034717.

Further reading

• Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Feb 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
• Machado RD, Pauciulo MW, Fretwell N, Veal C, Thomson JR, Vilariño Güell C, Aldred M, Brannon CA, Trembath RC, Nichols WC (Sep 2000). "A physical and transcript map based upon refinement of the critical interval for PPH1, a gene for familial primary pulmonary hypertension. The International PPH Consortium". Genomics. 68 (2): 220–8. doi:10.1006/geno.2000.6291. PMID 10964520.
• Beck M, Brickley K, Wilkinson HL, Sharma S, Smith M, Chazot PL, Pollard S, Stephenson FA (Aug 2002). "Identification, molecular cloning, and characterization of a novel GABAA receptor-associated protein, GRIF-1". The Journal of Biological Chemistry. 277 (33): 30079–90. doi:10.1074/jbc.M200438200. PMID 12034717.
• Iyer SP, Akimoto Y, Hart GW (Feb 2003). "Identification and cloning of a novel family of coiled-coil domain proteins that interact with O-GlcNAc transferase". The Journal of Biological Chemistry. 278 (7): 5399–409. doi:10.1074/jbc.M209384200. PMID 12435728.
• Brickley K, Smith MJ, Beck M, Stephenson FA (Apr 2005). "GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins: association in vivo and in vitro with kinesin". The Journal of Biological Chemistry. 280 (15): 14723–32. doi:10.1074/jbc.M409095200. PMID 15644324.
• Fransson S, Ruusala A, Aspenström P (Jun 2006). "The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking". Biochemical and Biophysical Research Communications. 344 (2): 500–10. doi:10.1016/j.bbrc.2006.03.163. PMID 16630562.
• Smith MJ, Pozo K, Brickley K, Stephenson FA (Sep 2006). "Mapping the GRIF-1 binding domain of the kinesin, KIF5C, substantiates a role for GRIF-1 as an adaptor protein in the anterograde trafficking of cargoes". The Journal of Biological Chemistry. 281 (37): 27216–28. doi:10.1074/jbc.M600522200. PMID 16835241.
• Grishin A, Li H, Levitan ES, Zaks-Makhina E (Oct 2006). "Identification of gamma-aminobutyric acid receptor-interacting factor 1 (TRAK2) as a trafficking factor for the K+ channel Kir2.1". The Journal of Biological Chemistry. 281 (40): 30104–11. doi:10.1074/jbc.M602439200. PMID 16895905.