TRAF interacting protein

TRAF-interacting protein is a protein that in humans is encoded by the TRAIP gene.[5][6]

TRAIP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4ZTD
Identifiers
Aliases	TRAIP, RNF206, TRIP, SCKL9, TRAF interacting protein
External IDs	OMIM: 605958 MGI: 1096377 HomoloGene: 31343 GeneCards: TRAIP
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.31 Start 49,828,601 bp[1] End 49,856,574 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 F1|9 59.07 cM Start 107,950,136 bp[2] End 107,972,270 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • ubiquitin-protein transferase activity • GO:0001948 protein binding • metal ion binding • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity • transferase activity • zinc ion binding Cellular component • cytoplasm • perinuclear region of cytoplasm • nucleolus • cell nucleus Biological process • cellular proliferation • protein ubiquitination • negative regulation of interferon-beta production • signal transduction • negative regulation of tumor necrosis factor-mediated signaling pathway • apoptotic process • negative regulation of NF-kappaB transcription factor activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10293	22036
Ensembl	ENSG00000183763	ENSMUSG00000032586
UniProt	Q9BWF2	Q8VIG6
RefSeq (mRNA)	NM_005879	NM_011634
RefSeq (protein)	NP_005870	NP_035764
Location (UCSC)	Chr 3: 49.83 – 49.86 Mb	Chr 9: 107.95 – 107.97 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a protein that contains an N-terminal RING finger motif and a putative coiled-coil domain. A similar murine protein interacts with TNFR-associated factor 1 (TRAF1), TNFR-associated factor 2 (TRAF2), and cylindromatosis. The interaction with TRAF2 inhibits TRAF2-mediated nuclear factor kappa-B, subunit 1 activation that is required for cell activation and protection against apoptosis.[6]

Interactions

TRAF interacting protein has been shown to interact with FLII,[7] TRAF1[5] and TRAF2.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000183763 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032586 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lee SY, Lee SY, Choi Y (April 1997). "TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation". The Journal of Experimental Medicine. 185 (7): 1275–85. doi:10.1084/jem.185.7.1275. PMC 2196258. PMID 9104814.
6. "Entrez Gene: TRAIP TRAF interacting protein".
7. Wilson SA, Brown EC, Kingsman AJ, Kingsman SM (August 1998). "TRIP: a novel double stranded RNA binding protein which interacts with the leucine rich repeat of flightless I". Nucleic Acids Research. 26 (15): 3460–7. doi:10.1093/nar/26.15.3460. PMC 147727. PMID 9671805.

Further reading

• Beckly JB, Hancock L, Geremia A, Cummings JR, Morris A, Cooney R, Pathan S, Guo C, Jewell DP (April 2008). "Two-stage candidate gene study of chromosome 3p demonstrates an association between nonsynonymous variants in the MST1R gene and Crohn's disease". Inflammatory Bowel Diseases. 14 (4): 500–7. doi:10.1002/ibd.20365. PMID 18200509.
• Regamey A, Hohl D, Liu JW, Roger T, Kogerman P, Toftgard R, Huber M (December 2003). "The tumor suppressor CYLD interacts with TRIP and regulates negatively nuclear factor kappaB activation by tumor necrosis factor". The Journal of Experimental Medicine. 198 (12): 1959–64. doi:10.1084/jem.20031187. PMC 2194148. PMID 14676304.
• Wilson SA, Brown EC, Kingsman AJ, Kingsman SM (August 1998). "TRIP: a novel double stranded RNA binding protein which interacts with the leucine rich repeat of flightless I". Nucleic Acids Research. 26 (15): 3460–7. doi:10.1093/nar/26.15.3460. PMC 147727. PMID 9671805.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

External links

• TRAIP human gene location in the UCSC Genome Browser.
• TRAIP human gene details in the UCSC Genome Browser.