TRAF3IP2

Adapter protein CIKS is a protein that in humans is encoded by the TRAF3IP2 gene.[5][6][7]

TRAF3IP2
Identifiers
Aliases	TRAF3IP2, ACT1, C6orf2, C6orf4, C6orf5, C6orf6, CANDF8, CIKS, PSORS13, TRAF3 interacting protein 2
External IDs	OMIM: 607043 MGI: 2143599 HomoloGene: 15885 GeneCards: TRAF3IP2
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q21 Start 111,555,381 bp[1] End 111,606,906 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 B1 Start 39,612,934 bp[2] End 39,655,307 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • receptor binding • GO:0001948 protein binding Cellular component • intracellular • cellular component Biological process • positive regulation of I-kappaB kinase/NF-kappaB signaling • immunoglobulin secretion • GO:0007243 intracellular signal transduction • humoral immune response • B cell apoptotic process • positive regulation of defense response to virus by host Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10758	103213
Ensembl	ENSG00000056972	ENSMUSG00000019842
UniProt	O43734	Q8N7N6
RefSeq (mRNA)	NM_001164281 NM_001164282 NM_001164283 NM_147200 NM_147686	NM_134000
RefSeq (protein)	NP_001157753 NP_001157755 NP_671733 NP_679211	NP_598761
Location (UCSC)	Chr 6: 111.56 – 111.61 Mb	Chr 10: 39.61 – 39.66 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. This gene product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Two alternative transcripts encoding different proteins have been identified. A third transcript, which does not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expression of at least one of the protein encoding transcripts, suggesting it has a regulatory role in the expression of this gene.[7]

Interactions

TRAF3IP2 has been shown to interact with IKBKG.[5][6]

References

1. GRCh38: Ensembl release 89: ENSG00000056972 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000019842 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Leonardi A, Chariot A, Claudio E, Cunningham K, Siebenlist U (Oct 2000). "CIKS, a connection to Ikappa B kinase and stress-activated protein kinase". Proc Natl Acad Sci U S A. 97 (19): 10494–9. doi:10.1073/pnas.190245697. PMC 27052. PMID 10962033.
6. Li X, Commane M, Nie H, Hua X, Chatterjee-Kishore M, Wald D, Haag M, Stark GR (Oct 2000). "Act1, an NF-kappa B-activating protein". Proc Natl Acad Sci U S A. 97 (19): 10489–93. doi:10.1073/pnas.160265197. PMC 27051. PMID 10962024.
7. "Entrez Gene: TRAF3IP2 TRAF3 interacting protein 2".

Further reading

• Morelli C, Magnanini C, Mungall AJ, et al. (2000). "Cloning and characterization of two overlapping genes in a subregion at 6q21 involved in replicative senescence and schizophrenia". Gene. 252 (1–2): 217–25. doi:10.1016/S0378-1119(00)00231-6. PMID 10903453.
• Qian Y, Zhao Z, Jiang Z, Li X (2002). "Role of NF kappa B activator Act1 in CD40-mediated signaling in epithelial cells". Proc. Natl. Acad. Sci. U.S.A. 99 (14): 9386–91. doi:10.1073/pnas.142294499. PMC 123150. PMID 12089335.
• Chariot A, Leonardi A, Muller J, et al. (2002). "Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases". J. Biol. Chem. 277 (40): 37029–36. doi:10.1074/jbc.M205069200. PMID 12133833.
• Xia YF, Li YD, Li X, Geng JG (2002). "Identification of alternatively spliced Act1 and implications for its roles in oncogenesis". Biochem. Biophys. Res. Commun. 296 (2): 406–12. doi:10.1016/S0006-291X(02)00887-2. PMID 12163033.
• Kanamori M, Kai C, Hayashizaki Y, Suzuki H (2003). "NF-kappaB activator Act1 associates with IL-1/Toll pathway adaptor molecule TRAF6". FEBS Lett. 532 (1–2): 241–6. doi:10.1016/S0014-5793(02)03688-8. PMID 12459498.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
• Mauro C, Vito P, Mellone S, et al. (2003). "Role of the adaptor protein CIKS in the activation of the IKK complex". Biochem. Biophys. Res. Commun. 309 (1): 84–90. doi:10.1016/S0006-291X(03)01532-8. PMID 12943667.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.