TP53INP1

Tumor protein p53-inducible nuclear protein 1 is a protein that in humans is encoded by the TP53INP1 gene.[5][6][7] In mice this protein is also called TRP53INP1 and is encoded by the Trp53inp1 gene. The protein is also referred to as SIP or "stress inducible protein"

TP53INP1
Identifiers
Aliases	TP53INP1, SIP, TP53DINP1, TP53INP1A, TP53INP1B, Teap, p53DINP1, tumor protein p53 inducible nuclear protein 1
External IDs	OMIM: 606185 MGI: 1926609 HomoloGene: 11065 GeneCards: TP53INP1
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q22.1 Start 94,925,972 bp[1] End 94,949,378 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 A1 Start 11,156,431 bp[2] End 11,174,379 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • antioxidant activity • GO:0001948 protein binding Cellular component • cytosol • PML body • autophagosome • cytoplasmic vesicle • cell nucleus • nucleoplasm • cytoplasm Biological process • regulation of transcription, DNA-templated • cellular response to ethanol • positive regulation of autophagy • cellular response to methyl methanesulfonate • cellular response to UV • cellular oxidant detoxification • positive regulation of apoptotic signaling pathway • response to heat • autophagosome assembly • transcription, DNA-templated • cellular response to hydroperoxide • positive regulation of transcription, DNA-templated • autophagy • negative regulation of cell migration • regulation of autophagy • cell cycle arrest • positive regulation of apoptotic process • autophagic cell death • negative regulation of cell proliferation • apoptotic process • regulation of apoptotic process • regulation of signal transduction by p53 class mediator • positive regulation of gene expression • negative regulation of gene expression • negative regulation of fibroblast proliferation • negative regulation of myofibroblast differentiation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	94241	60599
Ensembl	ENSG00000164938	ENSMUSG00000028211
UniProt	Q96A56	Q9QXE4
RefSeq (mRNA)	NM_001135733 NM_033285	NM_001199105 NM_021897
RefSeq (protein)	NP_001129205 NP_150601	NP_001186034 NP_068697
Location (UCSC)	Chr 8: 94.93 – 94.95 Mb	Chr 4: 11.16 – 11.17 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

TP53INP1 has been shown to interact with HIPK2[8] and p53.[5][8]

References

1. GRCh38: Ensembl release 89: ENSG00000164938 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028211 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Okamura S, Arakawa H, Tanaka T, Nakanishi H, Ng CC, Taya Y, Monden M, Nakamura Y (Aug 2001). "p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis". Mol Cell. 8 (1): 85–94. doi:10.1016/S1097-2765(01)00284-2. PMID 11511362.
6. Nowak J, Tomasini R, Mattei MG, Azizi Samir LA, Dagorn JC, Dusetti N, Iovanna JL, Pebusque MJ (Nov 2002). "Assignment of tumor protein p53 induced nuclear protein 1 (TP53INP1) gene to human chromosome band 8q22 by in situ hybridization". Cytogenet Genome Res. 97 (1–2): 140E. doi:10.1159/000064049. PMID 12438758.
7. "Entrez Gene: TP53INP1 tumor protein p53 inducible nuclear protein 1".
8. Tomasini, Richard; Samir Amina Azizi; Carrier Alice; Isnardon Daniel; Cecchinelli Barbara; Soddu Silvia; Malissen Bernard; Dagorn Jean-Charles; Iovanna Juan L; Dusetti Nelson J (Sep 2003). "TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity". J. Biol. Chem. United States. 278 (39): 37722–9. doi:10.1074/jbc.M301979200. ISSN 0021-9258. PMID 12851404.

Further reading

• Tomasini R, Samir AA, Pebusque MJ, et al. (2003). "P53-dependent expression of the stress-induced protein (SIP)". Eur. J. Cell Biol. 81 (5): 294–301. doi:10.1078/0171-9335-00248. PMID 12067065.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Tomasini R, Samir AA, Carrier A, et al. (2003). "TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity". J. Biol. Chem. 278 (39): 37722–9. doi:10.1074/jbc.M301979200. PMID 12851404.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Hershko T, Chaussepied M, Oren M, Ginsberg D (2005). "Novel link between E2F and p53: proapoptotic cofactors of p53 are transcriptionally upregulated by E2F". Cell Death Differ. 12 (4): 377–83. doi:10.1038/sj.cdd.4401575. PMID 15706352.
• Tomasini R, Seux M, Nowak J, et al. (2006). "TP53INP1 is a novel p73 target gene that induces cell cycle arrest and cell death by modulating p73 transcriptional activity". Oncogene. 24 (55): 8093–104. doi:10.1038/sj.onc.1208951. PMID 16044147.
• Jiang PH, Motoo Y, Garcia S, et al. (2006). "Down-expression of tumor protein p53-induced nuclear protein 1 in human gastric cancer". World J. Gastroenterol. 12 (5): 691–6. PMID 16521180.
• Ito Y, Motoo Y, Yoshida H, et al. (2007). "High level of tumour protein p53-induced nuclear protein 1 (TP53INP1) expression in anaplastic carcinoma of the thyroid". Pathology. 38 (6): 545–7. doi:10.1080/00313020601024094. PMID 17393983.
• Bernardo MV, Yelo E, Gimeno L, et al. (2007). "Identification of apoptosis-related PLZF target genes". Biochem. Biophys. Res. Commun. 359 (2): 317–22. doi:10.1016/j.bbrc.2007.05.085. PMID 17537403.