TOG superfamily

The transporter-opsin-G protein-coupled receptor (TOG) superfamily is a protein superfamily of integral membrane proteins, usually of 7 or 8 transmembrane alpha-helical segments (TMSs). It includes (1) ion-translocating microbial rhodopsins and (2) G protein-coupled receptors (GPCRs), (3) Sweet sugar transporters, (4) nicotinamide ribonucleoside uptake permeases (PnuC; TC# 4.B.1), (5) 4-toluene sulfonate uptake permeases (TSUP); TC# 2.A.102), (6) Ni²⁺–Co²⁺ transporters (NiCoT); TC# 2.A.52), (7) organic solute transporters (OST); TC# 2.A.82), (8) phosphate:Na⁺ symporters (PNaS); TC# 2.A.58) and (9) lysosomal cystine transporters (LCT); TC# 2.A.43).[1][2]

Families

Currently recognized families within the TOG Superfamily (with TC numbers in blue) include:[3]

• 1.A.14 - The Testis-enhanced Gene Transfer (TEGT) Family
• 1.A.26 - The Mg²⁺ Transporter-E (MgtE) Family
• 1.A.76 - The Magnesium Transporter1 (MagT1) Family
• 2.A.43 - The Lysosomal Cystine Transporter (LCT) Family
• 2.A.52 - The Ni²⁺-Co²⁺ Transporter (NiCoT) Family
• 2.A.58 - The Phosphate:Na⁺ Symporter (PNaS) Family
• 2.A.82 - The Organic Solute Transporter (OST) Family
• 2.A.102 - The 4-Toluene Sulfonate Uptake Permease (TSUP) Family
• 2.A.123 - The Sweet; PQ-loop; Saliva; MtN3 (Sweet) Family
• 3.E.1 - The Ion-translocating Microbial Rhodopsin (MR) Family
• 4.B.1 - The Nicotinamide Ribonucleoside (NR) Uptake Permease (PnuC) Family
• 9.A.14 - The G-protein-coupled receptor (GPCR) Family

Structures

A couple of the 3-D structures available for members of the following families include:

• SWEET family: 4RNG​
• MR family: 5AX0​, 3T45​ - high resolution structures
• PnuC family: 4QTN​
• GPCR family: 3CAP​

See also

• Solute carrier family
• Transporter Classification Database

References

1. Maksim A. Shlykov; Wei Hao Zheng; Jonathan S. Chen & Milton H. Saier, Jr.. (March 2012). "Bioinformatic Characterization of the 4-Toluene Sulfonate Uptake Permease (TSUP) Family of Transmembrane Proteins". Biochimica et Biophysica Acta (BBA) - Biomembranes. 1818 (3): 703–717. doi:10.1016/j.bbamem.2011.12.005. PMC 3917603. PMID 22192777.
2. Yee DC1, Shlykov MA, Västermark A, Reddy VS, Arora S, Sun EI, Saier MH Jr.. (September 2013). "The transporter-opsin-G protein-coupled receptor (TOG) superfamily". The FEBS Journal. 280 (22): 5780–5800. doi:10.1111/febs.12499. PMC 3832197. PMID 23981446.CS1 maint: multiple names: authors list (link)
3. Saier, Milton. "Transporter-Opsin-G protein-coupled receptor (TOG) Superfamily". tcdb.org. Retrieved 28 December 2015.

Further reading

• Yee DC1, Shlykov MA, Västermark A, Reddy VS, Arora S, Sun EI, Saier MH Jr.. (September 2013). "The transporter-opsin-G protein-coupled receptor (TOG) superfamily". The FEBS Journal. 280 (22): 5780–5800. doi:10.1111/febs.12499. PMC 3832197. PMID 23981446.CS1 maint: multiple names: authors list (link)