TNS4

Tensin-4 is a protein that in humans is encoded by the TNS4 gene.[5][6][7]

TNS4
Identifiers
Aliases	TNS4, CTEN, PP14434, tensin 4
External IDs	OMIM: 608385 MGI: 2144377 HomoloGene: 13147 GeneCards: TNS4
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.2 Start 40,475,828 bp[1] End 40,501,623 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 D Start 99,065,678 bp[2] End 99,089,306 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • actin binding • GO:0001948 protein binding Cellular component • cytoplasm • cell junction • cytoskeleton • focal adhesion • cytosol Biological process • protein localization • apoptotic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	84951	217169
Ensembl	ENSG00000131746	ENSMUSG00000017607
UniProt	Q8IZW8	Q8BZ33
RefSeq (mRNA)	NM_032865	NM_172564
RefSeq (protein)	NP_116254	NP_766152
Location (UCSC)	Chr 17: 40.48 – 40.5 Mb	Chr 11: 99.07 – 99.09 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000131746 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000017607 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lo SH, Lo TB (Aug 2002). "Cten, a COOH-terminal tensin-like protein with prostate restricted expression, is down-regulated in prostate cancer". Cancer Res. 62 (15): 4217–21. PMID 12154022.
6. Sasaki H, Moriyama S, Mizuno K, Yukiue H, Konishi A, Yano M, Kaji M, Fukai I, Kiriyama M, Yamakawa Y, Fujii Y (Apr 2003). "Cten mRNA expression was correlated with tumor progression in lung cancers". Lung Cancer. 40 (2): 151–5. doi:10.1016/S0169-5002(03)00037-0. PMID 12711115.
7. "Entrez Gene: TNS4 tensin 4".

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Sasaki H, Yukiue H, Kobayashi Y, et al. (2004). "Cten mRNA expression is correlated with tumor progression in thymoma". Tumour Biol. 24 (5): 271–4. doi:10.1159/000076141. PMID 15001839.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
• Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
• Lo SS, Lo SH, Lo SH (2005). "Cleavage of cten by caspase-3 during apoptosis". Oncogene. 24 (26): 4311–4. doi:10.1038/sj.onc.1208571. PMID 15806167.
• Liao YC, Si L, deVere White RW, Lo SH (2007). "The phosphotyrosine-independent interaction of DLC-1 and the SH2 domain of cten regulates focal adhesion localization and growth suppression activity of DLC-1". J. Cell Biol. 176 (1): 43–9. doi:10.1083/jcb.200608015. PMC 2063623. PMID 17190795.
• Katz M, Amit I, Citri A, et al. (2007). "A reciprocal tensin-3-cten switch mediates EGF-driven mammary cell migration". Nat. Cell Biol. 9 (8): 961–9. doi:10.1038/ncb1622. PMID 17643115.
• Mouneimne G, Brugge JS (2007). "Tensins: a new switch in cell migration". Dev. Cell. 13 (3): 317–9. doi:10.1016/j.devcel.2007.08.010. PMID 17765673.