TNIP2

TNFAIP3-interacting protein 2 is a protein that in humans is encoded by the TNIP2 gene.[5][6][7]

TNIP2
Identifiers
Aliases	TNIP2, ABIN2, FLIP1, KLIP, TNFAIP3 interacting protein 2
External IDs	OMIM: 610669 MGI: 2386643 HomoloGene: 11515 GeneCards: TNIP2
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p16.3 Start 2,741,648 bp[1] End 2,756,342 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 B2 Start 34,496,087 bp[2] End 34,513,991 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • protein kinase binding • metal ion binding • polyubiquitin modification-dependent protein binding • K63-linked polyubiquitin modification-dependent protein binding Cellular component • cell nucleus • cytosol • cytoplasm • nucleoplasm Biological process • negative regulation of endothelial cell apoptotic process • regulation of transcription, DNA-templated • CD40 signaling pathway • protein stabilization • positive regulation of macrophage activation • transcription, DNA-templated • stress-activated MAPK cascade • positive regulation of I-kappaB kinase/NF-kappaB signaling • positive regulation of B cell activation • inflammatory response • I-kappaB kinase/NF-kappaB signaling • positive regulation of transcription from RNA polymerase II promoter • apoptotic process • toll-like receptor 9 signaling pathway • toll-like receptor 2 signaling pathway • toll-like receptor 3 signaling pathway • protein deubiquitination • cellular response to lipopolysaccharide • interleukin-1-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	79155	231130
Ensembl	ENSG00000168884	ENSMUSG00000059866
UniProt	Q8NFZ5	Q99JG7
RefSeq (mRNA)	NM_024309 NM_001161527 NM_001292016	NM_139064
RefSeq (protein)	NP_001154999 NP_001278945 NP_077285	NP_620703
Location (UCSC)	Chr 4: 2.74 – 2.76 Mb	Chr 5: 34.5 – 34.51 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000168884 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000059866 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Van Huffel S, Delaei F, Heyninck K, De Valck D, Beyaert R (Aug 2001). "Identification of a novel A20-binding inhibitor of nuclear factor-kappa B activation termed ABIN-2". J Biol Chem. 276 (32): 30216–23. doi:10.1074/jbc.M100048200. PMID 11390377.
6. Tadros A, Hughes DP, Dunmore BJ, Brindle NP (Dec 2003). "ABIN-2 protects endothelial cells from death and has a role in the antiapoptotic effect of angiopoietin-1". Blood. 102 (13): 4407–9. doi:10.1182/blood-2003-05-1602. PMID 12933576.
7. "Entrez Gene: TNIP2 TNFAIP3 interacting protein 2".

Further reading

• Heyninck K, De Valck D, Vanden Berghe W, et al. (1999). "The Zinc Finger Protein A20 Inhibits TNF-induced NF-κB–dependent Gene Expression by Interfering with an RIP- or TRAF2-mediated Transactivation Signal and Directly Binds to a Novel NF-κB–inhibiting Protein ABIN". J. Cell Biol. 145 (7): 1471–82. doi:10.1083/jcb.145.7.1471. hdl:1854/LU-113881. PMC 2133159. PMID 10385526.
• Klinkenberg M, Van Huffel S, Heyninck K, Beyaert R (2001). "Functional redundancy of the zinc fingers of A20 for inhibition of NF-kappaB activation and protein-protein interactions". FEBS Lett. 498 (1): 93–7. doi:10.1016/S0014-5793(01)02504-2. PMID 11389905.
• Wu WS, Xu ZX, Chang KS (2002). "The promyelocytic leukemia protein represses A20-mediated transcription". J. Biol. Chem. 277 (35): 31734–9. doi:10.1074/jbc.M201648200. PMID 12080044.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Liu WK, Chien CY, Chou CK, Su JY (2003). "An LKB1-interacting protein negatively regulates TNFalpha-induced NF-kappaB activation". J. Biomed. Sci. 10 (2): 242–52. doi:10.1159/000068708. PMID 12595760.
• Hughes DP, Marron MB, Brindle NP (2003). "The antiinflammatory endothelial tyrosine kinase Tie2 interacts with a novel nuclear factor-kappaB inhibitor ABIN-2". Circ. Res. 92 (6): 630–6. doi:10.1161/01.RES.0000063422.38690.DC. PMID 12609966.
• Chien CY, Liu WK, Chou CK, Su JY (2003). "The A20-binding protein ABIN-2 exerts unexpected function in mediating transcriptional coactivation". FEBS Lett. 543 (1–3): 55–60. doi:10.1016/S0014-5793(03)00401-0. PMID 12753905.
• Liu WK, Yen PF, Chien CY, et al. (2004). "The inhibitor ABIN-2 disrupts the interaction of receptor-interacting protein with the kinase subunit IKKgamma to block activation of the transcription factor NF-kappaB and potentiate apoptosis". Biochem. J. 378 (Pt 3): 867–76. doi:10.1042/BJ20031736. PMC 1224013. PMID 14653779.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
• Lang V, Symons A, Watton SJ, et al. (2004). "ABIN-2 Forms a Ternary Complex with TPL-2 and NF-κB1 p105 and Is Essential for TPL-2 Protein Stability". Mol. Cell. Biol. 24 (12): 5235–48. doi:10.1128/MCB.24.12.5235-5248.2004. PMC 419892. PMID 15169888.
• Li CC, Chou CK, Wang MH, Tsai TF (2006). "Overexpression of ABIN-2, a negative regulator of NF-kappaB, delays liver regeneration in the ABIN-2 transgenic mice". Biochem. Biophys. Res. Commun. 342 (1): 300–9. doi:10.1016/j.bbrc.2006.01.114. PMID 16480954.
• Greenberg H, Ye X, Wilson D, et al. (2006). "Chronic intermittent hypoxia activates nuclear factor-kappaB in cardiovascular tissues in vivo". Biochem. Biophys. Res. Commun. 343 (2): 591–6. doi:10.1016/j.bbrc.2006.03.015. PMID 16554025.
• Liu Y, Nakahara T, Miyakoshi J, et al. (2007). "Nuclear accumulation and activation of nuclear factor kappaB after split-dose irradiation in LS174T cells". J. Radiat. Res. 48 (1): 13–20. doi:10.1269/jrr.0615. PMID 17038805.