TMSB10

Thymosin beta-10 is a protein that in humans is encoded by the TMSB10 gene.[3][4][5] TMSB10 is a member of the beta-thymosin family of peptides.

TMSB10
Identifiers
Aliases	TMSB10, MIG12, TB10, thymosin beta 10
External IDs	OMIM: 188399 GeneCards: TMSB10
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p11.2 Start 84,905,656 bp[1] End 84,906,671 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • actin binding • GO:0001948 protein binding • actin monomer binding Cellular component • cytoskeleton • cytoplasm Biological process • actin filament organization • regulation of cell migration • sequestering of actin monomers Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9168	n/a
Ensembl	ENSG00000034510	n/a
UniProt	P63313	n/a
RefSeq (mRNA)	NM_021103	n/a
RefSeq (protein)	NP_066926	n/a
Location (UCSC)	Chr 2: 84.91 – 84.91 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

TMSB10 plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).

References

1. GRCh38: Ensembl release 89: ENSG00000034510 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. McCreary V, Kartha S, Bell GI, Toback FG (Jun 1988). "Sequence of a human kidney cDNA clone encoding thymosin beta 10". Biochem Biophys Res Commun. 152 (2): 862–6. doi:10.1016/S0006-291X(88)80118-9. PMID 3365256.
4. Santelli G, Califano D, Chiappetta G, Vento MT, Bartoli PC, Zullo F, Trapasso F, Viglietto G, Fusco A (Oct 1999). "Thymosin beta-10 gene overexpression is a general event in human carcinogenesis". Am J Pathol. 155 (3): 799–804. doi:10.1016/s0002-9440(10)65178-4. PMC 1866886. PMID 10487837.
5. "Entrez Gene: TMSB10 thymosin, beta 10".

Further reading

• Tsitsiloni OE, Yialouris PP, Echner H, et al. (1992). "Evidence for the extranuclear localization of thymosins in thymus". Experientia. 48 (4): 398–402. doi:10.1007/BF01923441. PMID 1582498.
• Condon MR, Hall AK (1992). "Expression of thymosin beta-4 and related genes in developing human brain". J. Mol. Neurosci. 3 (3): 165–70. doi:10.1007/BF02919408. PMID 1627460.
• Lin SC, Morrison-Bogorad M (1992). "Cloning and characterization of a testis-specific thymosin beta 10 cDNA. Expression in post-meiotic male germ cells". J. Biol. Chem. 266 (34): 23347–53. PMID 1744129.
• Hall AK (1991). "Differential expression of thymosin genes in human tumors and in the developing human kidney". Int. J. Cancer. 48 (5): 672–7. doi:10.1002/ijc.2910480507. PMID 2071228.
• Hall AK, Hempstead J, Morgan JI (1990). "Thymosin beta 10 levels in developing human brain and its regulation by retinoic acid in the HTB-10 neuroblastoma". Brain Res. Mol. Brain Res. 8 (2): 129–35. doi:10.1016/0169-328X(90)90057-K. PMID 2169566.
• Weterman MA, van Muijen GN, Ruiter DJ, Bloemers HP (1993). "Thymosin beta-10 expression in melanoma cell lines and melanocytic lesions: a new progression marker for human cutaneous melanoma". Int. J. Cancer. 53 (2): 278–84. doi:10.1002/ijc.2910530218. PMID 8425765.
• Lapteva N, Ando Y, Nieda M, et al. (2001). "Profiling of genes expressed in human monocytes and monocyte-derived dendritic cells using cDNA expression array". Br. J. Haematol. 114 (1): 191–7. doi:10.1046/j.1365-2141.2001.02910.x. PMID 11472367.
• Bani-Yaghoub M, Felker JM, Ozog MA, et al. (2002). "Array analysis of the genes regulated during neuronal differentiation of human embryonal cells". Biochem. Cell Biol. 79 (4): 387–98. doi:10.1139/bcb-79-4-387. PMID 11527208.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Santelli G, Bartoli PC, Giuliano A, et al. (2003). "Thymosin beta-10 protein synthesis suppression reduces the growth of human thyroid carcinoma cells in semisolid medium". Thyroid. 12 (9): 765–72. doi:10.1089/105072502760339325. PMID 12481941.
• Johansson U, Olsson A, Gabrielsson S, et al. (2003). "Inflammatory mediators expressed in human islets of Langerhans: implications for islet transplantation". Biochem. Biophys. Res. Commun. 308 (3): 474–9. doi:10.1016/S0006-291X(03)01392-5. PMID 12914774.
• Rho SB, Chun T, Lee SH, et al. (2004). "The interaction between E-tropomodulin and thymosin beta-10 rescues tumor cells from thymosin beta-10 mediated apoptosis by restoring actin architecture". FEBS Lett. 557 (1–3): 57–63. doi:10.1016/S0014-5793(03)01438-8. PMID 14741341.
• Chiappetta G, Pentimalli F, Monaco M, et al. (2005). "Thymosin beta-10 gene expression as a possible tool in diagnosis of thyroid neoplasias". Oncol. Rep. 12 (2): 239–43. doi:10.3892/or.12.2.239. PMID 15254683.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Lee SH, Son MJ, Oh SH, et al. (2005). "Thymosin {beta}(10) inhibits angiogenesis and tumor growth by interfering with Ras function". Cancer Res. 65 (1): 137–48. PMID 15665289.
• Rho SB, Lee KW, Chun T, et al. (2005). "The identification of apoptosis-related residues in human thymosin beta-10 by mutational analysis and computational modeling". J. Biol. Chem. 280 (40): 34003–7. doi:10.1074/jbc.M501629200. PMID 16012174.
• Maelan AE, Rasmussen TK, Larsson LI (2007). "Localization of thymosin beta10 in breast cancer cells: relationship to actin cytoskeletal remodeling and cell motility". Histochem. Cell Biol. 127 (1): 109–13. doi:10.1007/s00418-006-0208-z. PMID 16786322.
• Kim SC, Sprung R, Chen Y, et al. (2006). "Substrate and functional diversity of lysine acetylation revealed by a proteomics survey". Mol. Cell. 23 (4): 607–18. doi:10.1016/j.molcel.2006.06.026. PMID 16916647.