TMF1

TATA element modulatory factor is a protein that in humans is encoded by the TMF1 gene.[4][5]

TMF1
Identifiers
Aliases	TMF1, ARA160, TMF, TATA element modulatory factor 1
External IDs	OMIM: 601126 MGI: 2684999 HomoloGene: 133801 GeneCards: TMF1
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p14.1 Start 69,019,827 bp[1] End 69,052,339 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • GO:0001104 transcription cofactor activity • GO:0001948 protein binding Cellular component • cytoplasm • Golgi apparatus • membrane • Golgi membrane • endoplasmic reticulum • cell nucleus • cytosol Biological process • flagellated sperm motility • regulation of proteasomal protein catabolic process • male gonad development • regulation of transcription, DNA-templated • Leydig cell differentiation • positive regulation of cytokine production • cellular response to organic cyclic compound • negative regulation of apoptotic process • transcription from RNA polymerase II promoter • negative regulation of gene expression • transcription, DNA-templated • positive regulation of testosterone secretion • defense response to bacterium • acrosome assembly • spermatid development • luteinizing hormone secretion • spermatid nucleus differentiation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7110	232286
Ensembl	ENSG00000144747	n/a
UniProt	P82094 Q6PII6	B9EKI3
RefSeq (mRNA)	NM_007114 NM_001363879	NM_001081111
RefSeq (protein)	NP_009045 NP_001350808 NP_009045.2	NP_001074580
Location (UCSC)	Chr 3: 69.02 – 69.05 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

TMF1 has been shown to interact with FER[6] and Androgen receptor.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000144747 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Garcia JA, Ou SH, Wu F, Lusis AJ, Sparkes RS, Gaynor RB (Nov 1992). "Cloning and chromosomal mapping of a human immunodeficiency virus 1 "TATA" element modulatory factor". Proc Natl Acad Sci U S A. 89 (20): 9372–6. Bibcode:1992PNAS...89.9372G. doi:10.1073/pnas.89.20.9372. PMC 50133. PMID 1409643.
5. "Entrez Gene: TMF1 TATA element modulatory factor 1".
6. Schwartz, Y; Ben-Dor I; Navon A; Motro B; Nir U (Sep 1998). "Tyrosine phosphorylation of the TATA element modulatory factor by the FER nuclear tyrosine kinases". FEBS Lett. 434 (3): 339–45. doi:10.1016/S0014-5793(98)01003-5. ISSN 0014-5793. PMID 9742951.
7. Hsiao, P W; Chang C (Aug 1999). "Isolation and characterization of ARA160 as the first androgen receptor N-terminal-associated coactivator in human prostate cells". J. Biol. Chem. 274 (32): 22373–9. doi:10.1074/jbc.274.32.22373. ISSN 0021-9258. PMID 10428808.

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Schwartz Y, Ben-Dor I, Navon A, et al. (1998). "Tyrosine phosphorylation of the TATA element modulatory factor by the FER nuclear tyrosine kinases". FEBS Lett. 434 (3): 339–45. doi:10.1016/S0014-5793(98)01003-5. PMID 9742951.
• Hsiao PW, Chang C (1999). "Isolation and characterization of ARA160 as the first androgen receptor N-terminal-associated coactivator in human prostate cells". J. Biol. Chem. 274 (32): 22373–9. doi:10.1074/jbc.274.32.22373. PMID 10428808.
• Mori K, Kato H (2002). "A putative nuclear receptor coactivator (TMF/ARA160) associates with hbrm/hSNF2 alpha and BRG-1/hSNF2 beta and localizes in the Golgi apparatus". FEBS Lett. 520 (1–3): 127–32. doi:10.1016/S0014-5793(02)02803-X. PMID 12044884.
• Zhang Y, Fondell JD, Wang Q, et al. (2002). "Repression of androgen receptor mediated transcription by the ErbB-3 binding protein, Ebp1". Oncogene. 21 (36): 5609–18. doi:10.1038/sj.onc.1205638. PMID 12165860.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Fridmann-Sirkis Y, Siniossoglou S, Pelham HR (2004). "TMF is a golgin that binds Rab6 and influences Golgi morphology". BMC Cell Biol. 5: 18. doi:10.1186/1471-2121-5-18. PMC 419336. PMID 15128430.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• Yamane J, Kubo A, Nakayama K, et al. (2007). "Functional involvement of TMF/ARA160 in Rab6-dependent retrograde membrane traffic" (PDF). Exp. Cell Res. 313 (16): 3472–85. doi:10.1016/j.yexcr.2007.07.010. PMID 17698061.