TMEM219

Transmembrane protein 219 also known as insulin-like growth factor-binding protein 3 receptor or IGFBP-3R is a protein that in humans is encoded by the TMEM219 gene.[5] IGFBP-3R acts as a cell death receptor for IGFBP3.[6]

TMEM219
Identifiers
AliasesTMEM219, IGFBP-3R, transmembrane protein 219
External IDsMGI: 1915992 HomoloGene: 19263 GeneCards: TMEM219
Gene location (Human)
Chr.Chromosome 16 (human)[1]
Band16p11.2Start29,940,885 bp[1]
End29,973,050 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

124446

68742

Ensembl

ENSG00000149932

ENSMUSG00000060538

UniProt

Q86XT9

Q9D123

RefSeq (mRNA)

NM_001083613
NM_194280

NM_026827
NM_028389
NM_001374613

RefSeq (protein)

NP_001077082
NP_919256
NP_001356617
NP_001356618
NP_001356619

NP_081103
NP_082665
NP_001361542

Location (UCSC)Chr 16: 29.94 – 29.97 MbChr 7: 126.89 – 126.92 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

References

  1. GRCh38: Ensembl release 89: ENSG00000149932 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000060538 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Transmembrane protein 219".
  6. Ingermann AR, Yang YF, Han J, Mikami A, Garza AE, Mohanraj L, Fan L, Idowu M, Ware JL, Kim HS, Lee DY, Oh Y (September 2010). "Identification of a novel cell death receptor mediating IGFBP-3-induced anti-tumor effects in breast and prostate cancer". J. Biol. Chem. 285 (39): 30233–46. doi:10.1074/jbc.M110.122226. PMC 2943278. PMID 20353938.


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